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Cat. No.: HY-P11775

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Peptide HRH

Peptide HRH is a polypeptide that specifically binds to VEGF receptors. Peptide HRH inhibits VEGF-stimulated endothelial cell proliferation. Peptide HRH inhibits angiogenesis and suppresses corneal neovascularization. Peptide HRH can be used in anti-angiogenesis related studies.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1228536-06-8
화학식: C₆₄H₁₀₄N₂₈O₁₆
분자량:1521.69

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

Peptide HRH Chemical Structure

CAS No.: 1228536-06-8

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All VEGFR Isoforms :

In Vitro

Peptide HRH (0.95-3.85 μg/μL; 96 h) dose-dependently inhibits the proliferation of VEGF-stimulated human umbilical vein endothelial cells (HUVECs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

human umbilical vein endothelial cells (HUVECs) stimulated with VEGF
Concentration:

0.95; 1.9; 3.85 μg/μL
Incubation Time:

96 h
Result:

Suppressed the proliferation of VEGF-stimulated HUVECs in a dose-dependent manner.

In Vivo

Peptide HRH (10-50 μg/μL; local application to CAM; 48 h) dose-dependently suppresses angiogenesis in the chick CAM model^[1].
Peptide HRH (10 μg/μL; topical eye drops; four times per day; 14 days) significantly inhibits corneal neovascularization in the alkali-burned rat corneal model^[1].
Peptide HRH (10 μg/μL; topical eye drops; four times per day; 14 days) significantly inhibits corneal neovascularization in the suture-induced rat corneal model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, alkali-burned corneal model)^[1]
Dosage:

10 μg/μL
Administration:

topical eye drops; four times per day; 14 days
Result:

Significantly reduced corneal neovascularization area from days 3 to 14 post-burn.
Kept most of the corneal stroma free of blood vessels.

Animal Model:

Sprague-Dawley (male, suture-induced corneal model)^[1]
Dosage:

10 μg/μL
Administration:

topical eye drops; four times per day; 14 days
Result:

Significantly reduced maximum vessel length and total corneal neovascularization area from days 3 to 14 post-suture.

Chemical Information

CAS No. 1228536-06-8
분자량 1521.69
화학식 C₆₄H₁₀₄N₂₈O₁₆
Sequence

His-Arg-His-Thr-Lys-Gln-Arg-His-Thr-Ala-Leu-His
Sequence Shortening

HRHTKQRHTALH
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. A novel peptide specifically binding to VEGF receptor suppresses angiogenesis in vitro and in vivo. Signal Transduct Target Ther. 2017 May 12;2:17010. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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CAS No.:
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Peptide HRH

All VEGFR Isoforms