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  2. Myosin
  3. Blebbistatin

Blebbistatin 

Cat. No.: HY-13813 Purity: >97.0%
Handling Instructions

Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function.

For research use only. We do not sell to patients.

Blebbistatin Chemical Structure

Blebbistatin Chemical Structure

CAS No. : 674289-55-5

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1 mg USD 255 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function[1].

IC50 & Target

Non-muscle myosin II (NMII)[1]

In Vitro

The therapeutic potential of targeting NMII to enhance CEC migration is investigated using bovine corneal endothelial cells (BCECs). Blebbistatin, a direct myosin motor inhibitor, promotes migration and directional persistence in CECs through decreasing actin retrograde flow and increasing lamellipodial protrusion persistence to accelerate wound healing in vitro[1].

In Vivo

Blebbistatin (0.05 mL, 20 μM; intracameral injection; daily; for 6 days; New Zealand white rabbits) treatment promotes wound healing in rabbit corneal endothelial scraping model[1].

Animal Model: New Zealand white rabbits (16-20 weeks; 3-3.5 kg) with injected xylazine 5 mg/kg and ketamine 40 mg/kg[1]
Dosage: 0.05 mL; 20 μM
Administration: Intracameral injection; daily; for 6 days
Result: Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer.
Molecular Weight

292.33

Formula

C₁₈H₁₆N₂O₂

CAS No.

674289-55-5

SMILES

O=C1C2(O)C(N(C3=CC=CC=C3)CC2)=NC4=C1C=C(C)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

BlebbistatinMyosinInhibitorinhibitorinhibit

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Blebbistatin
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