1. Cytoskeleton
  2. Myosin

(-)-Blebbistatin (Synonyms: (S)-(-)-Blebbistatin)

Cat. No.: HY-13441 Purity: 99.47%
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(-)-Blebbistatin is a selective inhibitor of myosin II ATPase activity with IC50 of 0.5 - 5 μM.

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(-)-Blebbistatin Chemical Structure

(-)-Blebbistatin Chemical Structure

CAS No. : 856925-71-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $66 In-stock
5 mg $60 In-stock
10 mg $100 In-stock
50 mg $350 Backordered
100 mg   Get quote  
200 mg   Get quote  

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Description

(-)-Blebbistatin is a selective inhibitor of myosin II ATPase activity with IC50 of 0.5 - 5 μM. IC50 value: 0.5 - 5 μM [1] Target: ATPase in vitro: Blebbistatin is a cell-permeable inhibitor of myosin II ATPase activity, promises to be a very useful tool for identifying and studying myosin II-dependent processes in cells. Blebbistatin inhibits the actin-activated MgATPase of Dictyostelium myosin II with an IC50 of 7 μM and 95% inhibition at 100 μM. Blebbistatin also inhibits cell streaming and plaque expansion in myosin II-null cells. [1] Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species, while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Blebbistatin potently inhibits Dictyostelium myosin II, but poorly inhibits Acanthamoeba myosin II.[2]

Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.4208 mL 17.1040 mL 34.2079 mL
5 mM 0.6842 mL 3.4208 mL 6.8416 mL
10 mM 0.3421 mL 1.7104 mL 3.4208 mL
M.Wt

292.33

Formula

C₁₈H₁₆N₂O₂

CAS No.

856925-71-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

Purity: 99.47%

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Product Name:
(-)-Blebbistatin
Cat. No.:
HY-13441
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