674289-55-5
674289-55-5
Chemical Structure
Blebbistatin
- CAS No.: 674289-55-5
- Formula:C18H16N2O2
- Molecular Weight:292.33
IUPAC Name: 3a-hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
InChIKey: LZAXPYOBKSJSEX-UHFFFAOYSA-N
SMILES: O=C1C2(O)C(N(C3=CC=CC=C3)CC2)=NC4=C1C=C(C)C=C4
Biological Activity: Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Blebbistatin | 99.57% | Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Blebbistatin (Standard) | ≥98% | Blebbistatin (Standard) is the analytical standard of Blebbistatin. This product is intended for research and analytical applications. Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. Blebbistatin blocks cell migration. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 1.00
HY-107657R(+)-Blebbistatin (Standard) -
Similarity Score 1.00
HY-13441(-)-Blebbistatin -
Similarity Score 0.85
HY-111474Para-aminoblebbistatin -
Similarity Score 0.84
HY-123634(S)-3'-Aminoblebbistatin -
Similarity Score 0.84
HY-129452(S)-3'-Hydroxy blebbistatin -
Similarity Score 0.80
HY-120870para-Nitroblebbistatin -
Similarity Score 0.77
HY-133885S-(-)-7-Desmethyl-8-nitro blebbistatin -
Similarity Score 0.77
HY-133885AR-(-)-7-Desmethyl-8-nitro blebbistatin -
Similarity Score 0.73
HY-174406AMT-125 free base -
Explore the MedChemAI to find more analogs
References
- [1]. Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl). 2019 Sep;97(9):1345-1357. [Content Brief]
- [2]. Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25(1):24-38. [Content Brief]
