para-Nitroblebbistatin
Based on 2 publication(s) in Google Scholar
para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology.
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- Pureza: 99.0%
- No. CAS: 1621326-32-6
- Fòrmula: C18H15N3O4
- Peso molecular:337.33
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Aficamten
Publications Citing Use of MedChemExpress (MCE) para-Nitroblebbistatin
More
Actividad biológica
Descripciòn
In Vitro
para-Nitroblebbistatin (0.31-10 μM; 24 h) can inhibit cytokinesis in COS-7 cells, resulting in a multinucleated phenotype in the cells, with an EC50 of 2.9 μM[1].
para-Nitroblebbistatin (10 μM; irradiated with 480 nM for 15 min; 18 h) is non-cytotoxic in HeLa cells, and there are no differences in cell mortality and morphology compared with the control group[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1621326-32-6
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Appearance Solid
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Peso molecular 337.33
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Fòrmula C18H15N3O4
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Color Yellow to orange
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SMILES
O=C1[C@]2(C(N(CC2)C3=CC=C(C=C3)[N+]([O-])=O)=NC4=C1C=C(C=C4)C)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Curr Biol
Dynamic shape-shifting of the single-celled eukaryotic predator Lacrymaria via unconventional cytoskeletal components. [Abstract]2024 Nov 4;34(21):4869-4883.e6. PMID: 39353425 -
Solvente y solubilidad
In Vitro:
DMSO : 22 mg/mL (65.22 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Radnai L, et al. A simple and robust cell-based assay for the discovery of novel cytokinesis inhibitors. J Biol Methods. 2020 Sep 17;7(3):e136. [Content Brief]
[2]. Képiró M, et al. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8211-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9645 mL | 14.8223 mL | 29.6446 mL | 74.1114 mL |
| 5 mM | 0.5929 mL | 2.9645 mL | 5.9289 mL | 14.8223 mL | |
| 10 mM | 0.2964 mL | 1.4822 mL | 2.9645 mL | 7.4111 mL | |
| 15 mM | 0.1976 mL | 0.9882 mL | 1.9763 mL | 4.9408 mL | |
| 20 mM | 0.1482 mL | 0.7411 mL | 1.4822 mL | 3.7056 mL | |
| 25 mM | 0.1186 mL | 0.5929 mL | 1.1858 mL | 2.9645 mL | |
| 30 mM | 0.0988 mL | 0.4941 mL | 0.9882 mL | 2.4704 mL | |
| 40 mM | 0.0741 mL | 0.3706 mL | 0.7411 mL | 1.8528 mL | |
| 50 mM | 0.0593 mL | 0.2964 mL | 0.5929 mL | 1.4822 mL | |
| 60 mM | 0.0494 mL | 0.2470 mL | 0.4941 mL | 1.2352 mL |
para-Nitroblebbistatin Related Classifications
HY-120870 Related Classifications
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