Para-aminoblebbistatin

Cat. No.: HY-111474 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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Para-aminoblebbistatin is a highly water soluble, non-fluorescent and photostable C15 amino-substituted derivative of blebbistatin; inhibits various (myosin II) isoforms both in vitro and in vivo.

For research use only. We do not sell to patients.

Para-aminoblebbistatin Chemical Structure

CAS No. : 2097734-03-5

Size	Price	Stock	Quantity
500 μg	USD 468	In-stock	Estimated Time of Arrival: December 31

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Myosin II^[1]

Molecular Weight

307.35

Formula

C₁₈H₁₇N₃O₂

CAS No.

2097734-03-5

Appearance

Solid

Color

Orange to red

SMILES

O=C1[C@@]2(O)C(N(C3=CC=C(N)C=C3)CC2)=NC4=CC=C(C)C=C41

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMF : 20 mg/mL (65.07 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2536 mL	16.2681 mL	32.5362 mL
5 mM	0.6507 mL	3.2536 mL	6.5072 mL
10 mM	0.3254 mL	1.6268 mL	3.2536 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (256 KB)

Handling Instructions (2659 KB)

References

[1]. Várkuti BH, et al. A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Sci Rep. 2016 May 31;6:26141. [Content Brief]

[2]. Képiró M, et al. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8211-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF	1 mM	3.2536 mL	16.2681 mL	32.5362 mL	81.3405 mL
	5 mM	0.6507 mL	3.2536 mL	6.5072 mL	16.2681 mL
	10 mM	0.3254 mL	1.6268 mL	3.2536 mL	8.1340 mL
	15 mM	0.2169 mL	1.0845 mL	2.1691 mL	5.4227 mL
	20 mM	0.1627 mL	0.8134 mL	1.6268 mL	4.0670 mL
	25 mM	0.1301 mL	0.6507 mL	1.3014 mL	3.2536 mL
	30 mM	0.1085 mL	0.5423 mL	1.0845 mL	2.7113 mL
	40 mM	0.0813 mL	0.4067 mL	0.8134 mL	2.0335 mL
	50 mM	0.0651 mL	0.3254 mL	0.6507 mL	1.6268 mL
	60 mM	0.0542 mL	0.2711 mL	0.5423 mL	1.3557 mL