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culture+broth

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Aminopeptidase (1) Antibiotic (9) Apoptosis (1) Bacterial (9) Endogenous Metabolite (2) Fungal (3) Glutathione S-transferase (1) GSK-3 (1) HSP (1) Interleukin Related (1) Parasite (1) STAT (1) Trk Receptor (1) β-catenin (1)
By Research Areas:	Cancer (6) Endocrinology (1) Infection (14) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101040

Telacebec 5+ Cited Publications Q203; IAP6	Bacterial Antibiotic	Infection
Telacebec (Q203) is a midazopyridine amide compound. Telacebec is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

HY-125319

Amidepsine A	Acyltransferase	Metabolic Disease
Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .

HY-N14690

Piperazinomycin	Fungal Antibiotic Bacterial	Infection
Piperazinomycin is an antifungal and antibacterial antibiotic. Piperazinomycin is isolated from the culture broth of Streptoverticillium olivoreticuli subsp. neoenacticus. Piperazinomycin inhibits the growth of fungi, yeasts and some Mycobacterium species. Piperazinomycin exhibits inhibitory activity against Trichophyton species .

HY-117517

NG-012	Trk Receptor	Cancer
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-117738

Benarthin	Aminopeptidase Endogenous Metabolite GSK-3 β-catenin Apoptosis	Metabolic Disease
Benarthin is an orally active Pyroglutamyl peptidase inhibitor, THY1 inhibitor (with a K_d value of 5.13e-08 M) and competitive PGP-1 inhibitor (K_i = 1.2 µM). Benarthin is isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. Benarthin disrupts the THY1-SFRP1 interaction, inhibits the activation of the GSK3α/β-β-catenin pathway, and reduces the upregulation of FASLG. Benarthin attenuates urothelial anoikis and reduces cell Apoptosis. Benarthin possesses iron-chelating activity. Benarthin maintains urothelial barrier integrity and blocks the pathological cascade of renal interstitial fibroblasts induced by HAP stimulation. Benarthin can be used in studies related to kidney stones .

HY-101040A

Telacebec ditosylate Q203 ditosylate; IAP6 ditosylate	Bacterial Antibiotic	Infection
Telacebec ditosylate is a midazopyridine amide compound. Telacebec ditosylate is active against Mycobacterium tuberculosis H37Rv with an MIC₅₀ of 2.7 nM in culture broth medium.

HY-B1921

Miocamycin Midecamycin acetate; Ponsinomycin	Bacterial	Infection
Miocamycin (Midecamycin acetate) is a derivative of midecamycin (HY-B1908), a macrolide antibiotic that can be isolated from a culture broth of Streptomyces mycarofaciens. Miocamycin has antibacterial properties .

HY-N9085

Neuchromenin	Bacterial	Neurological Disease
Neuchromenin is a microbial melabolite that can be isolated from the culture broth of Eupenicillium javanicum var. meloforme PFll81. Neuchromenin induces neurite outgrowth of PC12 cells .

HY-N12656

Versipelostatin	HSP	Cancer
Versipelostatin is a GRP78/Bip molecular chaperone down-regulator and can be isolated from the culture broth of Streptomyces versipellis 4083-SVS6 .

HY-N7307

Pachybasin	Bacterial	Infection
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .

HY-114585A

Sperabillin A dihydrochloride	Glutathione S-transferase	Others
Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp .

HY-114521

5-(4-Methoxyphenyl)oxazole	Parasite	Infection
5-(4'-Methoxyphenyl)-oxazole is a Caenorhabditis elegans hatch and growth inhibitor that isolated from fungal culture broth .

HY-129295

Amidepsine D	Acyltransferase	Metabolic Disease
Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .

HY-N14180

6-Deoxyilludin M	Antibiotic	Infection Cancer
6-Deoxyilludin M is an antitumor antibiotic possessing antileukemic activity. 6-Deoxyilludin M can be isolated from the culture broth of the Basidiomycota Pleurotus japonicas .

HY-N6181

Terrelumamide A	Others	Endocrinology
Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .

HY-N15028

Depsidomycin	Antibiotic Bacterial	Infection Inflammation/Immunology
Depsidomycin is an immunomodulatory antibiotic with immunosuppressive activity that can be isolated from the culture broth of Streptomyces lavendofoliae MI951-62F2. Depsidomycin primarily exhibits antibacterial activity against Gram-positive bacteria .

HY-122191

AK-Toxin II	Others	Infection
AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K ⁺ loss on susceptible pear leaves .

HY-125349

A-83016F	Antibiotic	Infection
A-83016F is an antibiotic. A-83016F has weak antimicrobial activity. A-83016F can be isolated from the culture broth of an unidentified actinomycete designated A83016 .

HY-126735

Saquayamycin D	Antibiotic Bacterial	Infection
Saquayamycin D is an antibiotic, which can be isolated from Streptomyces nodosus culture broth. Saquayamycin D exhibits antibacterial activity against various gram-positive bacteria with MIC of 12.5-50 μg/mL. Saquayamycin D inhibits the proliferation of Doxorubicin (HY-15142)-sensitive P388/S and Doxorubicin-resistant P388/ADR with IC₅₀ of 0.15 and 0.15 μg/mL .

HY-117092

BE-31405	Antibiotic Fungal	Infection
BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candida albicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells .

HY-P1708

Enopeptin A BRN 537924; NSC 657143	Bacterial	Infection
Enopeptin A, originally isolated from a culture broth of Streptomyces sp. RK-1051, is a depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain. It is effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC=25 μg/mL), and Gram-negative bacteria, including mutant forms of E. coli and P. aeruginosa (MICs=200 μg/mL); however, it is not inhibitory to fungi.

HY-N14778

N-Acetylisopenicillin N	Others	Others
N-Acetylisopenicillin N is isolated from the culture broth of Streptomyces tokunonensis sp. nov .

HY-N10237

Mycestericin C	Others	Cancer
Mycestericin C is a compound isolated from the culture broth of Mycelia sterilia ATCC 20349. Mycestericin C suppresses the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction .

HY-N15263

Cepafungin III	Antibiotic Fungal	Infection Cancer
Cepafungin III is an acylpeptide antibiotic that can be isolated from the culture broth of Pseudomonas species. Cepafungin III exhibits inhibitory activity against yeast and fungi, and antitumor activity against P388 leukemia in mice, when mixed with Cepafungin I and II .

HY-N18989

Cyclo(L-Ile-D-Leu)	STAT Interleukin Related Endogenous Metabolite	Cancer
Cyclo (L-Ile-D-Leu) (Compound 15) is a STAT3 inhibitor. Cyclo (L-Ile-D-Leu) is isolated from the culture broth of Lactococcus lactis KR-050L. Cyclo (L-Ile-D-Leu) inhibits IL-6-induced STAT3 activation in cancer cells. Cyclo (L-Ile-D-Leu) is applicable to hepatocellular carcinoma research .

Amidepsine A	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Disease Research Fields Source Classification	Acyltransferase
Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .

Piperazinomycin	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal Antibiotic Bacterial
Piperazinomycin is an antifungal and antibacterial antibiotic. Piperazinomycin is isolated from the culture broth of Streptoverticillium olivoreticuli subsp. neoenacticus. Piperazinomycin inhibits the growth of fungi, yeasts and some Mycobacterium species. Piperazinomycin exhibits inhibitory activity against Trichophyton species .

NG-012	Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification Cancer	Trk Receptor
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

Neuchromenin	Natural Products Microorganisms Source Classification	Bacterial
Neuchromenin is a microbial melabolite that can be isolated from the culture broth of Eupenicillium javanicum var. meloforme PFll81. Neuchromenin induces neurite outgrowth of PC12 cells .

Versipelostatin	Structural Classification Natural Products Microorganisms Source Classification	HSP
Versipelostatin is a GRP78/Bip molecular chaperone down-regulator and can be isolated from the culture broth of Streptomyces versipellis 4083-SVS6 .

Pachybasin	Infection Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Phenols Disease Research Fields Source Classification	Bacterial
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .

Sperabillin A dihydrochloride	Microorganisms Classification of Application Fields Antibiotics Other Diseases Disease Research Fields Other Antibiotics Source Classification	Glutathione S-transferase
Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp .

6-Deoxyilludin M	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic
6-Deoxyilludin M is an antitumor antibiotic possessing antileukemic activity. 6-Deoxyilludin M can be isolated from the culture broth of the Basidiomycota Pleurotus japonicas .

Terrelumamide A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Marine natural products Endogenous metabolite Disease Research Fields Marine microorganism Endocrinology Source Classification	Others
Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .

Depsidomycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Depsidomycin is an immunomodulatory antibiotic with immunosuppressive activity that can be isolated from the culture broth of Streptomyces lavendofoliae MI951-62F2. Depsidomycin primarily exhibits antibacterial activity against Gram-positive bacteria .

AK-Toxin II	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Others
AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K ⁺ loss on susceptible pear leaves .

N-Acetylisopenicillin N	Natural Products Microorganisms Source Classification	Others
N-Acetylisopenicillin N is isolated from the culture broth of Streptomyces tokunonensis sp. nov .

Mycestericin C	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Cancer Source Classification	Others
Mycestericin C is a compound isolated from the culture broth of Mycelia sterilia ATCC 20349. Mycestericin C suppresses the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction .

Cepafungin III	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Fungal
Cepafungin III is an acylpeptide antibiotic that can be isolated from the culture broth of Pseudomonas species. Cepafungin III exhibits inhibitory activity against yeast and fungi, and antitumor activity against P388 leukemia in mice, when mixed with Cepafungin I and II .

Cyclo(L-Ile-D-Leu)	Structural Classification Microorganisms Cyclopeptides Source Classification	STAT Interleukin Related Endogenous Metabolite
Cyclo (L-Ile-D-Leu) (Compound 15) is a STAT3 inhibitor. Cyclo (L-Ile-D-Leu) is isolated from the culture broth of Lactococcus lactis KR-050L. Cyclo (L-Ile-D-Leu) inhibits IL-6-induced STAT3 activation in cancer cells. Cyclo (L-Ile-D-Leu) is applicable to hepatocellular carcinoma research .

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culture+broth

Inhibitors & Agonists

NaturalProducts

Natural
Products