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Pathways Recommended:	Anti-infection

Results for "

dermatophyte infection

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (1) Antibiotic (1) Apoptosis (1) Autophagy (1) Bacterial (2) Calcineurin (1) Cytochrome P450 (1) Fungal (14) GLUT (1) Isotope-Labeled Compounds (1) mTOR (1) p38 MAPK (1) Parasite (1) PI3K (1) PPAR (1) Reactive Oxygen Species (ROS) (1) SOD (1)
By Research Areas:	Cancer (3) Infection (14) Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0319

Tioconazole 4 Publications Verification UK-20349	Fungal Antibiotic Parasite Akt PI3K mTOR Autophagy	Infection Cancer
Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC₅₀ values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy .

HY-119847

Abafungin BAY-W-6341	Fungal	Infection
Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses .

HY-W984782

Flindersine	GLUT Bacterial Fungal AMPK PPAR Reactive Oxygen Species (ROS) Apoptosis SOD	Infection Metabolic Disease Cancer
Flindersine is an alkaloid with multiple activities including antibacterial, antifungal, antitumor, and antidiabetic properties. Flindersine increases the activity of antioxidant enzymes, restores the levels of renal biomarkers, and reduces blood glucose, blood lipid, and insulin levels in diabetic rats. Flindersine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, drug-resistant bacteria, as well as dermatophytes, filamentous fungi, and yeasts. Flindersine reduces the viability of cancer cells and induces apoptosis. Flindersine can be used in research related to breast cancer, type 2 diabetes, bacterial infections, and fungal infections .

HY-B1133

Sulbentine 1 Publications Verification Dibenzthione	Fungal	Infection
Sulbentine (Dibenzthione) is a thiadiazine-class antifungal agent. Sulbentine exhibits fungicidal and fungistatic activity against Trichophyton mentagrophytes. Sulbentine can be used for the research of dermatophyte infection .

HY-114518

Butenafine KP363	Fungal	Infection
Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as tinea pedis, tinea cruris, tinea versicolor .

HY-N11546

Sapindoside B	Cytochrome P450 Bacterial Fungal	Infection Cancer
Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .

HY-171796

Bromomonilicin	Fungal	Infection
Bromomonilicin is a selective fungal cell membrane inhibitor. Bromomonilicin exerts antifungal activity by disrupting fungal cell membrane integrity. Bromomonilicin is promising for research of plant pathogenic fungal infections (e.g., Monilinia fructicola-induced brown rot) and superficial mycoses (e.g., dermatophyte infections) .

HY-139903

Antifungal agent 18	Fungal Calcineurin p38 MAPK	Infection
Antifungal agent 18 is an antifungal agent. Antifungal agent 18 shows a broad-spectrum antifungal activity against major human fungal pathogens. Antifungal agent 18 compromises fungal cell wall integrity by targeting the unfolded protein response (UPR), calcineurin, and MAPK pathways. Antifungal agent 18 shows antifungal activity in virto and vivo. Antifungal agent 18 can be used for the research of invasive fungal pathogens and cutaneous dermatophytes .

HY-114518S2

Butenafine-d4 KP363-d₄	Fungal Isotope-Labeled Compounds	Infection
Butenafine-d4 (KP363-d4) is the deuterium labeled Butenafine (HY-114518). Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as ?tinea pedis, ?tinea cruris, tinea versicolor .

HY-10445

Pramiconazole Azoline; R126638	Fungal	Infection
Pramiconazole is a broad-spectrum antifungal agent with oral activity. Pramiconazole has a good affinity for 14α-demethylase. Pramiconazole can be used in the study of fungal infections in the local skin, hair, nails, oral cavity, and genital mucosa .

HY-106546

Tolciclate KC 9147	Fungal	Infection
Tolciclate (KC 9147) is an antifungal agent with in vitro inhibitory activity against dermatophytes, effective at concentrations of 0.01-0.1 μg/mL. Tolciclate is colorless and soluble in well-tolerated excipients, and it is more lipophilic than Tolnaftate (HY-B0370). Tolciclate can be used in research related to antifungal infections .

HY-N19757

(3β,16α-Hydroxy)-3-O-(2'acetamido-2'-deoxy-β-D-glucopyranosyl) echinocystic acid	Fungal	Infection
3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid is an oleanane-type triterpenoid saponin. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid acts as a dermatophyte growth inhibitor with a MIC range of 6.25-25 μg/mL. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid can be used in the research of dermatophyte infections, bacterial infections and yeast infections .

HY-N19881

Drimenal	Fungal	Infection
Drimenal is a pimarane-type natural sesquiterpene with antifungal activity. Drimenal inhibits the growth of yeasts and *dermatophytes. Drimenal can be used for the development of pesticide candidates and in research related to fungal infections* .

HY-W069116

Antifungal agent 146	Fungal	Infection
Antifungal agent 146 (Compound 19l) is a broad-spectrum antifungal agent. Antifungal agent 146 has inhibitory effects on the main dermatophytes that cause onychomycosis (Trichophyton rubrum, Trichophyton mentagrophytes) and other fungi (Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus) with MIC values of 16, 16, 64, 32, and 32 μg/mL. Antifungal agent 146 can be used for the research of infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W984782

Flindersine	Structural Classification Alkaloids Rutaceae Quinoline Alkaloids Plants Haplophyllum tuberculatum (Forssk.) A.Juss. Source Classification	GLUT Bacterial Fungal AMPK PPAR Reactive Oxygen Species (ROS) Apoptosis SOD
Flindersine is an alkaloid with multiple activities including antibacterial, antifungal, antitumor, and antidiabetic properties. Flindersine increases the activity of antioxidant enzymes, restores the levels of renal biomarkers, and reduces blood glucose, blood lipid, and insulin levels in diabetic rats. Flindersine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, drug-resistant bacteria, as well as dermatophytes, filamentous fungi, and yeasts. Flindersine reduces the viability of cancer cells and induces apoptosis. Flindersine can be used in research related to breast cancer, type 2 diabetes, bacterial infections, and fungal infections .

HY-N11546

Sapindoside B	Structural Classification Eleutherococcus sieboldianus Makino Terpenoids Diterpenoids Plants Araliaceae Source Classification	Cytochrome P450 Bacterial Fungal
Sapindoside B is a substance with hepatoprotective activity, and also acts as a cytochrome P-450 (cytochrome P-450) inhibitor, antibacterial agent and membrane-disrupting agent. Sapindoside B reversibly inhibits the content of cytochrome P-450 in liver microsomes, suppresses the phenobarbital-induced increase in enzyme content, reduces the production of active metabolites mediated by cytochrome P-450, and alleviates hepatotoxic injury. Sapindoside B binds to Cutibacterium acnes lipase, reduces lipase activity, inhibits biofilm formation, and decreases bacterial adhesion. Sapindoside B exhibits cytotoxicity against human cancer, liver cancer, leukemia and glioblastoma cells. Sapindoside B inhibits mycelial growth of phytopathogenic fungal strains, possesses antibacterial activity against dermatophytes, and also has hemolytic/membrane-lytic activity. Sapindoside B can be used in research related to liver injury, Cutibacterium acnes biofilm-associated infections, gastric cancer, carcinoma, promyelocytic leukemia, glioblastoma, apple scab and grape gray mold .

HY-N19757

(3β,16α-Hydroxy)-3-O-(2'acetamido-2'-deoxy-β-D-glucopyranosyl) echinocystic acid	Triterpenes Structural Classification Leguminosae Terpenoids Archidendron lucidum (Benth.) I. C. Nielsen Plants Source Classification	Fungal
3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid is an oleanane-type triterpenoid saponin. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid acts as a dermatophyte growth inhibitor with a MIC range of 6.25-25 μg/mL. 3-O-(2-Acetamido-2-deoxy-β-D-glucopyranosyl) echinocystic acid can be used in the research of dermatophyte infections, bacterial infections and yeast infections .

HY-N19881

Drimenal	Structural Classification Natural Products Bazzania trilobata (L.) Gray Lepidoziaceae Plants Source Classification	Fungal
Drimenal is a pimarane-type natural sesquiterpene with antifungal activity. Drimenal inhibits the growth of yeasts and *dermatophytes. Drimenal can be used for the development of pesticide candidates and in research related to fungal infections* .

Cat. No.	Product Name	Chemical Structure

HY-114518S2

Butenafine-d4
Butenafine-d4 (KP363-d4) is the deuterium labeled Butenafine (HY-114518). Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as ?tinea pedis, ?tinea cruris, tinea versicolor .

Butenafine-d4

Butenafine-d4 (KP363-d4) is the deuterium labeled Butenafine (HY-114518). Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as ?tinea pedis, ?tinea cruris, tinea versicolor .

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