2. Membrane Transporter/Ion Channel Anti-infection PI3K/Akt/mTOR Epigenetics Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage NF-κB Immunology/Inflammation Apoptosis
  3. GLUT Bacterial Fungal AMPK PPAR Reactive Oxygen Species (ROS) Apoptosis SOD
  4. Flindersine

Flindersine is an alkaloid with multiple activities including antibacterial, antifungal, antitumor, and antidiabetic properties. Flindersine increases the activity of antioxidant enzymes, restores the levels of renal biomarkers, and reduces blood glucose, blood lipid, and insulin levels in diabetic rats. Flindersine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, drug-resistant bacteria, as well as dermatophytes, filamentous fungi, and yeasts. Flindersine reduces the viability of cancer cells and induces apoptosis. Flindersine can be used in research related to breast cancer, type 2 diabetes, bacterial infections, and fungal infections.

For research use only. We do not sell to patients.

Flindersine

Flindersine Chemical Structure

CAS No. : 523-64-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Flindersine Related Antibodies

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GLUT1 GLUT2 GLUT3 GLUT4

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • Biological Activity

  • Purity & Documentation

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Description

Flindersine is an alkaloid with multiple activities including antibacterial, antifungal, antitumor, and antidiabetic properties. Flindersine increases the activity of antioxidant enzymes, restores the levels of renal biomarkers, and reduces blood glucose, blood lipid, and insulin levels in diabetic rats. Flindersine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, drug-resistant bacteria, as well as dermatophytes, filamentous fungi, and yeasts. Flindersine reduces the viability of cancer cells and induces apoptosis. Flindersine can be used in research related to breast cancer, type 2 diabetes, bacterial infections, and fungal infections[1][2][3].

In Vitro

Flindersine (50-200 μM; 24 h) reduces the viability of MDA-MB-231 and MCF-7 human breast cancer cells in a dose-dependent manner (with stronger efficacy against MDA-MB-231 cells), but has no effect on the viability of HUVEC[1].
Flindersine (50-200 μM; 24 h) dose-dependently downregulates the protein expression of GLUT1, HK2 and LDHA in MDA-MB-231 and MCF-7 human breast cancer cells, with a stronger efficacy in MDA-MB-231 cells[1].
Flindersine (50-200 μM; 24 h) dose-dependently reduces LDHA enzyme activity, intracellular ATP production, glucose uptake, and lactate production in MDA-MB-231 and MCF-7 human breast cancer cells, with greater potency in MDA-MB-231 cells[1].
Flindersine (50-200 μM; 24 h) dose-dependently induces apoptosis in human breast cancer cell lines MDA-MB-231 and MCF-7, with stronger efficacy against MDA-MB-231 cells[1].
Flindersine (24 h) exhibits moderate in vitro antibacterial activity against Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Gram-negative bacterium Pseudomonas aeruginosa, and drug-resistant bacterium Acinetobacter baumannii, with MIC values ranging from 31.25 to 250 μg/mL, but shows no activity against most other tested Gram-negative bacteria and drug-resistant bacteria[2].
Flindersine (0-9 days) exhibits moderate in vitro antifungal activity against the dermatophytes Trichophyton mentagrophytes, Trichophyton simii, Trichophyton rubrum 57, Epidermophyton floccosum, Trichophyton rubrum 296, the filamentous fungus Magnaporthe grisea, and the yeast Candida albicans, with MIC values ranging from 62.5 to 250 μg/mL, but shows no activity against other tested fungi[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flindersine Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231, MCF-7
Concentration: 50, 100, 200 μM
Incubation Time: 24 h
Result: Dose-dependently suppressed GLUT1, HK2, and LDHA protein expression by 20-80% in MDA-MB-231 cells compared to control.
Reduced GLUT1 expression by 65% in MDA-MB-231 cells at 200 μM.
Reduced GLUT1 expression by 65% in MCF-7 cells at 200 μM.
Dose-dependently reduced HK2 and LDHA expression by 25-65% in MCF-7 cells compared to control.
Exerted greater effects on reducing glycolytic protein expression in MDA-MB-231 cells than in MCF-7 cells.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231, MCF-7
Concentration: 50, 100, 200 μM
Incubation Time: 24 h
Result: Increased the percentage of apoptotic cells from 4.25% (control) to 15.81%, 29.5%, and 43.6% in MDA-MB-231 cells at 50, 100, and 200 μM respectively.
Increased the percentage of apoptotic cells from 2.1% (control) to 12.41%, 20.32%, and 34.1% in MCF-7 cells at 50, 100, and 200 μM respectively.
In Vivo

Flindersine (20-40 mg/kg; daily administration; for 28 consecutive days) exhibits potent antidiabetic, lipid-regulating and antioxidant activities in high-fat diet-Streptozotocin (HY-13753)-induced type 2 diabetic rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (male, 180-200 g, high-fat diet + streptozotocin-induced type 2 diabetes)[3]
Dosage: 10 mg/kg; 20 mg/kg; 40 mg/kg
Administration: daily; 28 days
Result: Lowered blood glucose levels.
Reduced final body weight gain, plasma insulin levels, AST, ALT, ALP, urea, creatinine, total cholesterol, triglycerides, and free fatty acid levels.
Increased total protein levels, SOD activity.
Increased CAT and GPx activities.
Increased GLUT4, AMPK, and PPARγ mRNA and protein expression in adipose tissue and skeletal muscles.
Molecular Weight

227.26

Formula

C14H13NO2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1NC2=C(C3=C1C=CC(C)(C)O3)C=CC=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (440.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4002 mL 22.0012 mL 44.0025 mL
5 mM 0.8800 mL 4.4002 mL 8.8005 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4002 mL 22.0012 mL 44.0025 mL 110.0062 mL
5 mM 0.8800 mL 4.4002 mL 8.8005 mL 22.0012 mL
10 mM 0.4400 mL 2.2001 mL 4.4002 mL 11.0006 mL
15 mM 0.2933 mL 1.4667 mL 2.9335 mL 7.3337 mL
20 mM 0.2200 mL 1.1001 mL 2.2001 mL 5.5003 mL
25 mM 0.1760 mL 0.8800 mL 1.7601 mL 4.4002 mL
30 mM 0.1467 mL 0.7334 mL 1.4667 mL 3.6669 mL
40 mM 0.1100 mL 0.5500 mL 1.1001 mL 2.7502 mL
50 mM 0.0880 mL 0.4400 mL 0.8800 mL 2.2001 mL
60 mM 0.0733 mL 0.3667 mL 0.7334 mL 1.8334 mL
80 mM 0.0550 mL 0.2750 mL 0.5500 mL 1.3751 mL
100 mM 0.0440 mL 0.2200 mL 0.4400 mL 1.1001 mL
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Flindersine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flindersine523-64-8GLUTBacterialFungalAMPKPPARReactive Oxygen Species (ROS)ApoptosisSODGlucose transporter AMP-activated protein kinasePeroxisome proliferator-activated receptorsSuperoxide DismutaseMDA-MB-231Bacillus subtilisMCF-7PPARγGLUT4type 2 diabetes mellitusHK2GLUT1LDHAInhibitorinhibitorinhibit

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