523-64-8
Chemical Structure
Flindersine
- CAS No.: 523-64-8
- Formula:C14H13NO2
- Molecular Weight:227.26
InChIKey: PXNMNABLQWUMCX-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C3=C1C=CC(C)(C)O3)C=CC=C2
Biological Activity: Flindersine is an alkaloid with multiple activities including antibacterial, antifungal, antitumor, and antidiabetic properties. Flindersine increases the activity of antioxidant enzymes, restores the levels of renal biomarkers, and reduces blood glucose, blood lipid, and insulin levels in diabetic rats. Flindersine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, drug-resistant bacteria, as well as dermatophytes, filamentous fungi, and yeasts. Flindersine reduces the viability of cancer cells and induces apoptosis. Flindersine can be used in research related to breast cancer, type 2 diabetes, bacterial infections, and fungal infections[1][2][3].
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Flindersine | 99.80% | Flindersine is an alkaloid with multiple activities including antibacterial, antifungal, antitumor, and antidiabetic properties. Flindersine increases the activity of antioxidant enzymes, restores the levels of renal biomarkers, and reduces blood glucose, blood lipid, and insulin levels in diabetic rats. Flindersine inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, drug-resistant bacteria, as well as dermatophytes, filamentous fungi, and yeasts. Flindersine reduces the viability of cancer cells and induces apoptosis. Flindersine can be used in research related to breast cancer, type 2 diabetes, bacterial infections, and fungal infections. | ||||||||||||||||||||
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- [1]. Moghtaderi H, et al. Flindersine from Haplophyllum tuberculatum modulates glycolysis and promotes apoptosis in breast cancer: Insights from in vitro, electrochemical, and molecular docking studies. Pharmacological Research-Natural Products, 2025: 100427.
- [2]. Duraipandiyan V, et al. Antibacterial and antifungal activity of Flindersine isolated from the traditional medicinal plant, Toddalia asiatica (L.) Lam. J Ethnopharmacol. 2009;123(3):494-498. [Content Brief]
- [3]. Irudayaraj SS, et al. Antidiabetic with antilipidemic and antioxidant effects of flindersine by enhanced glucose uptake through GLUT4 translocation and PPARγ agonism in type 2 diabetic rats. J Ethnopharmacol. 2022;285:114883. [Content Brief]
Keywords
