Drimenal 

Drimenal is a pimarane-type natural sesquiterpene with antifungal activity. Drimenal inhibits the growth of yeasts and dermatophytes. Drimenal can be used for the development of pesticide candidates and in research related to fungal infections^[1][2].

Drimenal-derived chiral oxazinone derivatives exhibit potent antifungal activity against Botrytis cinerea and antibacterial activity against Bacillus subtilis and Ralstonia solanacearum, with improved efficacy over the parent compound and positive controls streptomycin sulfate^[1].
Drimenal exhibits moderate fungicidal antifungal activity against Candida albicans ATCC 10231, Saccharomyces cerevisiae ATCC 9763, Cryptococcus neoformans ATCC 32264, Microsporum gypseum CCC 115, Trichophyton rubrum CCC 113, and Trichophyton mentagrophytes ATCC 9972, with MIC₁₀₀ values ranging from 31.2 to 125 µg/mL and MIC₅₀ values of 62.5 µg/mL against both C. albicans and C. neoformans^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

220.35

C₁₅H₂₄O

105426-71-9

C[C@@]12[C@](CC=C([C@@H]2C=O)C)([H])C(C)(CCC1)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li D, et al. Synthesis and bio-inspired optimization of drimenal: Discovery of chiral drimane fused oxazinones as promising antifungal and antibacterial candidates. Eur J Med Chem. 2018;143:558-567.

  [2]. Derita M, et al. Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies. Molecules. 2013;18(2):2029-2051. Published 2013 Feb 5.