Search Result
Results for "
dystrophin
" in MedChemExpress (MCE) Product Catalog:
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- HY-P990051
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AOC-1001 Antibody; AOC-1044 Antibody
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Transferrin Receptor
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Neurological Disease
Inflammation/Immunology
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Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research .
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- HY-132586
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NS-065/NCNP-01
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Nucleoside Antimetabolite/Analog
Dystrophin
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Metabolic Disease
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Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen has the potential for Duchenne muscular dystrophy (DMD) research .
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- HY-119850
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ARM036; S44121
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Calcium Channel
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Cardiovascular Disease
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Aladorian (ARM036; S44121) is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy .
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- HY-145724
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Kyndrisa; GSK2402968A; PRO051
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DNA/RNA Synthesis
Dystrophin
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Neurological Disease
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Drisapersen (Kyndrisa) is a 2 '-O-methyl phosphorothioate RNA antisense oligonucleotide that induces exon 51 skipping. Drisapersen induces skipping of exon 51 during Dystrophin pre-mRNA splicing, allowing the synthesis of partially functional Dystrophin. Drisapersen can be used in research related to Duchenne muscular dystrophy .
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- HY-132586A
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NS-065/NCNP-01 sodium
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Nucleoside Antimetabolite/Analog
Dystrophin
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Metabolic Disease
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Viltolarsen (NS-065/NCNP-01) sodium is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen sodium binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen sodium has the potential for Duchenne muscular dystrophy (DMD) research .
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- HY-147253
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NS 089; NCNP 02
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DNA/RNA Synthesis
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Neurological Disease
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Brogidirsen (NS 089; NCNP 02) is a a dual-targeting antisense oligonucleotide. Brogidirsen can induce dystrophin protein experession. Brogidirsen can be used for the research of Duchenne muscular dystrophy .
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- HY-177564
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Del-zota; AOC 1044
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Antibody-Oligonucleotide Conjugates (AOCs)
Transferrin Receptor
Dystrophin
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Neurological Disease
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Delpacibart zotadirsen (Del-zota), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated to a phosphorodiamidate morpholino conjugate (PMO), Delpacibart zotadirsen is designed to deliver phosphorodiamidate morpholino oligomers (PMOs) to skeletal muscle and heart tissue to specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin. Delpacibart zotadirsen is used for the study of myotonic dystrophy type 1 (DM1) .
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- HY-122631
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CDK
Dystrophin
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Others
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TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research .
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- HY-101459
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Dystrophin
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Metabolic Disease
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RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD) .
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- HY-132584A
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SRP-4045 sodium
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Dystrophin
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Neurological Disease
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Casimersen (SRP-4045) sodium is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen sodium binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen sodium can be used for the research of Duchenne muscular dystrophy (DMD) .
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- HY-177649
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Dystrophin
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Others
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Nivudirsen is an antisense oligonucleotide that can promote the synthesis of functional dystrophin protein.
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- HY-123359
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DNA/RNA Synthesis
Dystrophin
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Others
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RTC14 is a read-through compound (RTC) that can induce ribosomes to bypass nonsense mutations in mRNA and allow the production of full-length functional proteins. RTC14 has the potential to be used in the research of various genetic disorders, such as nonsense mutations in the ataxia-telangiectasia mutated (ATM) gene and the dystrophin gene .
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- HY-177658
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DS-5141b
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Dystrophin
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Others
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Renadirsen is an antisense oligonucleotide that induces robust Exon 45 skipping for Dystrophin in vivo.
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- HY-177659
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Dystrophin
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Others
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Rimigorsen is an antisense oligonucleotide that induces skipping of exon 44 of the pre-mRNA encoding dystrophin in a Duchenne muscular dystrophy (DMD)
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- HY-122588A
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Antibiotic
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Cardiovascular Disease
Metabolic Disease
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Negamycin (hydrochloride) is a dipeptide antibiotic. Negamycin (hydrochloride) can restore dystrophin expression in skeletal and cardiac muscles in mdx Duchenne muscular dystrophy (DMD) murine model. Negamycin (hydrochloride) can bind to a partial sequence of the eukaryotic rRNA-decoding A-site. Negamycin (hydrochloride) can be studied in DMD research .
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- HY-163665
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Aryl Hydrocarbon Receptor
Dystrophin
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Others
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AHR antagonist 8 (compound SG-02) is a regulator of utrophin, a homolog of dystrophin, and an AhR antagonist (Kd: 41.68 nM). Studies have shown that 800 nM of AHR antagonist 8 can upregulate utrophin by 2.7 times. AHR antagonist 8 also stimulates increased MyHC expression, suggesting that it has the potential to enhance myogenesis. After ADME evaluation, AHR antagonist 8 also has a certain oral bioavailability .
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- HY-147253A
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NS 089 sodium; NCNP 02 sodium
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DNA/RNA Synthesis
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Neurological Disease
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Brogidirsen (NS 089; NCNP 02) sodium is a a dual-targeting antisense oligonucleotide. Brogidirsen sodium can induce dystrophin protein experession. Brogidirsen sodium can be used for the research of Duchenne muscular dystrophy .
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- HY-150237
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DNA/RNA Synthesis
Dystrophin
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Others
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FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
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- HY-177649A
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Dystrophin
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Others
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Nivudirsen sodium is an antisense oligonucleotide that can promote the synthesis of functional dystrophin protein.
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- HY-177659A
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Dystrophin
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Others
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Rimigorsen sodium is an antisense oligonucleotide that induces skipping of exon 44 of the pre-mRNA encoding dystrophin in a Duchenne muscular dystrophy (DMD)
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- HY-W893751
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Biochemical Assay Reagents
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Metabolic Disease
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PMO-G is a spherical-shape polymeric micelles. PMO-G has skin permeation. PMO-G can result in up to a 50-fold higher level of dystrophin in abdominal muscles of mdx mice. PMO-G can be studied in research on Duchenne muscular dystrophy .
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- HY-119850A
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ARM036 sodium; S44121 sodium
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Calcium Channel
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Cardiovascular Disease
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Aladorian (ARM036; S44121) sodium is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian sodium stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian sodium improves cardiomyocyte Ca 2+ homeostasis independent of dystrophin restoration. Aladorian sodium attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian sodium can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy .
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- HY-101459R
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Dystrophin
Reference Standards
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Metabolic Disease
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RTC13 (Standard) is the analytical standard of RTC13 (HY-101459). This product is intended for research and analytical applications. RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD) .
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- HY-132584
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SRP-4045
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Dystrophin
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Neurological Disease
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Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen can be used for the research of Duchenne muscular dystrophy (DMD) .
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- HY-177658A
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DS-5141b sodium
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Dystrophin
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Others
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Renadirsen sodium is an antisense oligonucleotide that induces robust Exon 45 skipping for Dystrophin in vivo.
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- HY-185321
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Dystrophin
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Others
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Tacadirsen is an oligonucleotide that can promote the synthesis of functional dystrophin synthesis, and is used for the research of Duchenne muscular dystrophy.
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- HY-185321A
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Dystrophin
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Others
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Tacadirsen sodium is an oligonucleotide that can promote the synthesis of functional dystrophin synthesis, and is used for the research of Duchenne muscular dystrophy.
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- HY-177972
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Antibody-Oligonucleotide Conjugates (AOCs)
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Neurological Disease
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Zotadirsen, one of the components of the AOC Delpacibart zotadirsen (HY-177564), is composed of a phosphorodiamidate morpholino oligomers (PMOs) and SMCC linker (HY-42360). Zotadirsen specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin. Zotadirsen can be used to synthesize AOC drugs. Zotadirsen can also be used in the research of Duchenne muscular dystrophy (DM) .
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- HY-P11741
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Exosomes
Biochemical Assay Reagents
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Neurological Disease
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BV2 is a delivery peptide that binds to BVES, with a Ka of 2.03 μM for the BVES target. BV2 specifically binds to the extracellular domain of BVES, achieving muscle homing and cellular internalization via caveolae-mediated endocytosis. When BV2 is modified on the surface of exosomes by PMO, it enhances dystrophin restoration in the peripheral muscles and myocardium of dystrophin-deficient mice. BV2 is applicable to research related to Duchenne muscular dystrophy and muscle atrophy .
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- HY-P11741
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Exosomes
Biochemical Assay Reagents
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Neurological Disease
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BV2 is a delivery peptide that binds to BVES, with a Ka of 2.03 μM for the BVES target. BV2 specifically binds to the extracellular domain of BVES, achieving muscle homing and cellular internalization via caveolae-mediated endocytosis. When BV2 is modified on the surface of exosomes by PMO, it enhances dystrophin restoration in the peripheral muscles and myocardium of dystrophin-deficient mice. BV2 is applicable to research related to Duchenne muscular dystrophy and muscle atrophy .
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| 製品番号 |
製品名 |
Target |
研究分野 |
Image |
-
- HY-P990051
-
|
AOC-1001 Antibody; AOC-1044 Antibody
|
Transferrin Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
Delpacibart is a humanized IgG1κ monoclonal antibody targeting the transferrin receptor TFRC. Delpacibart can be conjugated with the phosphorodiamidate morpholino oligonucleotide (PMO) Zotadirsen (HY-177972), which targets exon 44 of the dystrophin gene, to synthesize the antibody-oligonucleotide conjugate (AOC) Delpacibart zotadirsen (HY-177564). Delpacibart is suitable for use in Duchenne muscular dystrophy (DMD44) research .
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(5)
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- HY-132586
-
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NS-065/NCNP-01
|
|
Antisense Oligonucleotides
|
|
Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen has the potential for Duchenne muscular dystrophy (DMD) research .
|
-
- HY-145724
-
|
Kyndrisa; GSK2402968A; PRO051
|
|
Antisense Oligonucleotides
|
|
Drisapersen (Kyndrisa) is a 2 '-O-methyl phosphorothioate RNA antisense oligonucleotide that induces exon 51 skipping. Drisapersen induces skipping of exon 51 during Dystrophin pre-mRNA splicing, allowing the synthesis of partially functional Dystrophin. Drisapersen can be used in research related to Duchenne muscular dystrophy .
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- HY-108753A
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AVI 4658 sodium
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Antisense Oligonucleotides
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Eteplirsen (AVI 4658) sodium is a synthetic antisense oligonucleotide that induces dystrophin production. Eteplirsen (AVI 4658) sodium promotes exon 51 skipping in Duchenne muscular dystrophy patients and can be used in Duchenne muscular dystrophy research .
|
-
- HY-132586A
-
|
NS-065/NCNP-01 sodium
|
|
Antisense Oligonucleotides
|
|
Viltolarsen (NS-065/NCNP-01) sodium is a phosphorodiamidate morpholino antisense oligonucleotide. Viltolarsen sodium binds to exon 53 of the dystrophin mRNA precursor and restores the amino acid open-reading frame by skipping exon 53, resulting in the production of a shortened dystrophin protein that contains essential functional portions. Viltolarsen sodium has the potential for Duchenne muscular dystrophy (DMD) research .
|
-
- HY-147253
-
|
NS 089; NCNP 02
|
|
Antisense Oligonucleotides
|
|
Brogidirsen (NS 089; NCNP 02) is a a dual-targeting antisense oligonucleotide. Brogidirsen can induce dystrophin protein experession. Brogidirsen can be used for the research of Duchenne muscular dystrophy .
|
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- HY-145724A
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Kyndrisa sodium; GSK2402968A sodium; PRO051 sodium
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Antisense Oligonucleotides
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Drisapersen sodium, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
|
-
- HY-132584A
-
|
SRP-4045 sodium
|
|
Antisense Oligonucleotides
|
|
Casimersen (SRP-4045) sodium is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen sodium binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen sodium can be used for the research of Duchenne muscular dystrophy (DMD) .
|
-
- HY-177649
-
|
|
|
Antisense Oligonucleotides
|
|
Nivudirsen is an antisense oligonucleotide that can promote the synthesis of functional dystrophin protein.
|
-
- HY-177658
-
|
DS-5141b
|
|
Antisense Oligonucleotides
|
|
Renadirsen is an antisense oligonucleotide that induces robust Exon 45 skipping for Dystrophin in vivo.
|
-
- HY-177659
-
|
|
|
Antisense Oligonucleotides
|
|
Rimigorsen is an antisense oligonucleotide that induces skipping of exon 44 of the pre-mRNA encoding dystrophin in a Duchenne muscular dystrophy (DMD)
|
-
- HY-147253A
-
|
NS 089 sodium; NCNP 02 sodium
|
|
Antisense Oligonucleotides
|
|
Brogidirsen (NS 089; NCNP 02) sodium is a a dual-targeting antisense oligonucleotide. Brogidirsen sodium can induce dystrophin protein experession. Brogidirsen sodium can be used for the research of Duchenne muscular dystrophy .
|
-
- HY-150237
-
|
|
|
Antisense Oligonucleotides
|
|
FITC-labeled Drisapersen (sodium) is Drisapersen labeled with FITC. Drisapersen, a antisense oligonucleotide, induces exon 51 skipping during dystrophin pre-mRNA splicing and allows synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations.
|
-
- HY-177649A
-
|
|
|
Antisense Oligonucleotides
|
|
Nivudirsen sodium is an antisense oligonucleotide that can promote the synthesis of functional dystrophin protein.
|
-
- HY-177659A
-
|
|
|
Antisense Oligonucleotides
|
|
Rimigorsen sodium is an antisense oligonucleotide that induces skipping of exon 44 of the pre-mRNA encoding dystrophin in a Duchenne muscular dystrophy (DMD)
|
-
- HY-132584
-
|
SRP-4045
|
|
Antisense Oligonucleotides
|
|
Casimersen (SRP-4045) is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen can be used for the research of Duchenne muscular dystrophy (DMD) .
|
-
- HY-177658A
-
|
DS-5141b sodium
|
|
Antisense Oligonucleotides
|
|
Renadirsen sodium is an antisense oligonucleotide that induces robust Exon 45 skipping for Dystrophin in vivo.
|
-
- HY-185321
-
|
|
|
Antisense Oligonucleotides
|
|
Tacadirsen is an oligonucleotide that can promote the synthesis of functional dystrophin synthesis, and is used for the research of Duchenne muscular dystrophy.
|
-
- HY-185321A
-
|
|
|
Antisense Oligonucleotides
|
|
Tacadirsen sodium is an oligonucleotide that can promote the synthesis of functional dystrophin synthesis, and is used for the research of Duchenne muscular dystrophy.
|
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