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Cat. No.: HY-177564

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Delpacibart zotadirsen

Name: Delpacibart zotadirsen
Brand: MedChemExpress
SKU: HY-177564
Price: 1720.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Del-zota; AOC 1044)

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Based on 1 Customer Validation

Delpacibart zotadirsen (Del-zota), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated to a phosphorodiamidate morpholino conjugate (PMO), Delpacibart zotadirsen is designed to deliver phosphorodiamidate morpholino oligomers (PMOs) to skeletal muscle and heart tissue to specifically skip exon 44 of the dystrophin gene and enable production of near-full length dystrophin. Delpacibart zotadirsen is used for the study of myotonic dystrophy type 1 (DM1).

For research use only. We do not sell to patients.

Purity: 92.88%
CAS No.: 2929240-20-8

Storage:

-80°C, protect from light

Delpacibart zotadirsen Chemical Structure

CAS No.: 2929240-20-8

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Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

All Antibody-Oligonucleotide Conjugates (AOCs) Isoforms :

In Vitro

Delpacibart zotadirsen is primarily used in the study of Duchenne muscular dystrophy with exon 44 skipping mutations (DMD44), and can cover both ambulatory and non-ambulatory patients aged 7-27 years^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2929240-20-8
Appearance Liquid
Color Colorless to light yellow
SMILES

[Delpacibart zotadirsen]
Synonyms

Del-zota; AOC 1044
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use. WO2025177244A1

[2]. Etxaniz U, Marks I, Albin T, et al. AOC 1044 induces exon 44 skipping and restores dystrophin protein in preclinical models of Duchenne muscular dystrophy. Nucleic Acids Res. 2025;53(6):gkaf241.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References

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Delpacibart zotadirsen

All Antibody-Oligonucleotide Conjugates (AOCs) Isoforms