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RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD).

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RTC13 Chemical Structure

RTC13 Chemical Structure

CAS No. : 1359825-94-7

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

RTC13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy (DMD)[1].
In Vivo
Animal Model: Wild-type (C57BL/10) mice at 10 to 12 weeks of age[1].
Dosage: 10 (n = 5), 30 (n = 5), 60 (n = 5) or 300 mg/kg (n = 5).
Administration: Intraperitoneal Administration.
Result: No changes were observed in liver and kidney weights at the time of necropsies, and Hematoxylin and Eosin (H&E) staining revealed the absence of histopathological changes.
Molecular Weight

315.30

Formula

C14H9N3O4S
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=[N+](C1=C(C=CC=C1)C2=CC=C(/C=C3C(NC(S/3)=N)=O)O2)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (317.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1716 mL 15.8579 mL 31.7158 mL
5 mM 0.6343 mL 3.1716 mL 6.3432 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1716 mL 15.8579 mL 31.7158 mL 79.2896 mL
5 mM 0.6343 mL 3.1716 mL 6.3432 mL 15.8579 mL
10 mM 0.3172 mL 1.5858 mL 3.1716 mL 7.9290 mL
15 mM 0.2114 mL 1.0572 mL 2.1144 mL 5.2860 mL
20 mM 0.1586 mL 0.7929 mL 1.5858 mL 3.9645 mL
25 mM 0.1269 mL 0.6343 mL 1.2686 mL 3.1716 mL
30 mM 0.1057 mL 0.5286 mL 1.0572 mL 2.6430 mL
40 mM 0.0793 mL 0.3964 mL 0.7929 mL 1.9822 mL
50 mM 0.0634 mL 0.3172 mL 0.6343 mL 1.5858 mL
60 mM 0.0529 mL 0.2643 mL 0.5286 mL 1.3215 mL
80 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9911 mL
100 mM 0.0317 mL 0.1586 mL 0.3172 mL 0.7929 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RTC131359825-94-7RTC 13RTC-13OthersDMDDuchenne muscular dystrophydystrophinInhibitorinhibitorinhibit

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