Aladorian sodium
Aladorian (ARM036; S44121) sodium is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian sodium stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian sodium improves cardiomyocyte Ca2+ homeostasis independent of dystrophin restoration. Aladorian sodium attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian sodium can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy.
For research use only. We do not sell to patients.
- CAS No.: 1233219-11-8
- Formula: C12H12NNaO4S
- Molecular Weight:289.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Calcium Channel |
Aladorian (ARM036) sodium produces a characteristic product ion mass spectrum when analyzed via high resolution/high accuracy mass spectrometry at a collision energy of 25 eV, with its protonated molecular ion detected at m/z 268.0639[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1233219-11-8
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Molecular Weight 289.28
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Formula C12H12NNaO4S
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SMILES
O=C(C(N1CCSC2=CC=C(C=C2C1)OC)=O)O[Na]
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Synonyms
ARM036 sodium; S44121 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Luo M, et al. Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res. 2013 Aug 30;113(6):690-708. [Content Brief]
[2]. Kupatt C, et al. Ryanodine Receptors Matter for Cardiac Function in Duchenne Muscular Dystrophy: Stability First. J Am Coll Cardiol. 2021 Dec 14;78(24):2454-2456. [Content Brief]
[5]. Thevis M, et al. Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls. J Pharm Biomed Anal. 2014 Dec;101:66-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aladorian sodium Related Classifications
HY-119850A Related Classifications
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