1233219-11-8
Chemical Structure
Aladorian sodium
Synonym(s): ARM036 sodium; S44121 sodium
- CAS. Nr.: 1233219-11-8
- Formula:C12H12NNaO4S
- Molecular Weight:289.28
IUPAC Name: sodium 2-(7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)-2-oxoacetate
InChIKey: OUNBYSZUAWDKLT-UHFFFAOYSA-M
SMILES: O=C(C(N1CCSC2=CC=C(C=C2C1)OC)=O)O[Na]
Biological Activity: Aladorian (ARM036; S44121) sodium is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian sodium stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian sodium improves cardiomyocyte Ca2+ homeostasis independent of dystrophin restoration. Aladorian sodium attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian sodium can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Aladorian sodium | Aladorian (ARM036; S44121) sodium is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian sodium stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian sodium improves cardiomyocyte Ca2+ homeostasis independent of dystrophin restoration. Aladorian sodium attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian sodium can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Luo M, et al. Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res. 2013 Aug 30;113(6):690-708. [Content Brief]
- [2]. Kupatt C, et al. Ryanodine Receptors Matter for Cardiac Function in Duchenne Muscular Dystrophy: Stability First. J Am Coll Cardiol. 2021 Dec 14;78(24):2454-2456. [Content Brief]
- [3]. Thireau J, et al. Anti-arrhythmic Effect of a Novel Rycal, S44121/Arm036, in a Post-myocardial Infarction Mouse Model of Heart Failure. Circulation. 2014;130( Suppl 2 ):Abstract 18592.
