Dystrophin Antibody (YA5775)

Cat. No.: HY-P86083: Ficha de datos COA
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Dystrophin Antibody (YA5775) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dystrophin.

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Tamaño	Stock	Cantidad
20 μL	En stock	Estimated Time of Arrival: December 31
50 μL	En stock	Estimated Time of Arrival: December 31
100 μL	En stock	Estimated Time of Arrival: December 31
250 μL	Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

Dystrophin Antibody (YA5775) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dystrophin.

Host

Rabbit

Clonality

Monoclonal

Peso molecular

Predicted band size: 427 kDa;

Observed band size: 427 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P11532

Gene ID

1756 [NCBI]

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
WB WB: Western Blot	1:500-1:2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-1:20000

Pureza	Protein A	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission

Subcellular Localization：Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytoskeleton; Postsynaptic cell membrane

Expression：
Tissue_specificity:This gene is expressed in myofibrils and accumulates in the sarcoplasm of the sarcolemma. It is expressed in the brain, muscle, kidneys, lungs, and testes. Multiple transcriptotypes are present in most tissues. Isotype 15: Detected only in the heart and liver, but also expressed in brain, testicular, and liver cancer cells.

Isoforms & Post-Translational Modification：P11532 has 17 isomers: P11532-1: 426778 Da (predicted); P11532-4: 425668 Da (predicted); P11532-11: 426029 Da (predicted); P11532-2: 271419 Da (predicted); P11532-3: 271068 Da (predicted); P11532-12: 141399 Da (predicted); P11532-13: 128978 Da (predicted); P11532-14: 143215 Da (predicted); P11532-15: 141774 Da (predicted); P11532-16: 130794 Da (predicted); P11532-17: 109970 Da (predicted); P11532-7: 70375 Da (predicted); P11532-8: 68934 Da (predicted); P11532-6: 72191 Da (predicted); P11532-5: 70750 Da (predicted); P11532-9: 59769 Da (predicted); P11532-18: 39254 Da (predicted).

Subunit：Interacts with the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2 (PubMed:7844150, PubMed:8576247). Interacts with KRT19 (PubMed:16000376).

Documentación

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Ficha de datos (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)