2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Dystrophin Antibody (YA3224)

Dystrophin Antibody (YA3224)

Cat. No.: HY-P83479
User Guide for Antibodies Technical Support

Dystrophin Antibody (YA3224) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dystrophin.

For research use only. We do not sell to patients.

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50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
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250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

  • References

Description

Dystrophin Antibody (YA3224) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dystrophin.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 427 kDa;
Observed band size: 427 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Dystrophin aa3611-3685.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission
Subcellular Localization：Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytoskeleton; Postsynaptic cell membrane
Expression：
Tissue_specificity:This gene is expressed in myofibrils and accumulates in the sarcoplasm of the sarcolemma. It is expressed in the brain, muscle, kidneys, lungs, and testes. Multiple transcriptotypes are present in most tissues. Isotype 15: Detected only in the heart and liver, but also expressed in brain, testicular, and liver cancer cells.
Isoforms & Post-Translational Modification：P11532 has 17 isomers: P11532-1: 426778 Da (predicted); P11532-4: 425668 Da (predicted); P11532-11: 426029 Da (predicted); P11532-2: 271419 Da (predicted); P11532-3: 271068 Da (predicted); P11532-12: 141399 Da (predicted); P11532-13: 128978 Da (predicted); P11532-14: 143215 Da (predicted); P11532-15: 141774 Da (predicted); P11532-16: 130794 Da (predicted); P11532-17: 109970 Da (predicted); P11532-7: 70375 Da (predicted); P11532-8: 68934 Da (predicted); P11532-6: 72191 Da (predicted); P11532-5: 70750 Da (predicted); P11532-9: 59769 Da (predicted); P11532-18: 39254 Da (predicted).
Subunit：Interacts with the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2 (PubMed:7844150, PubMed:8576247). Interacts with KRT19 (PubMed:16000376).
Database

Entrez Gene: 1756 Human ; 13405 Mouse ;

SwissProt: P11532 Human ; P11531 Mouse ; P11530 Rat

OMIM: 310200 Human

Research Field

Signal Transduction
Synonyms
BMD; CMD3B; DMD; Dystrophin
Documentation
User Guide for Antibodies (1077 KB)
References

Dystrophin Antibody (YA3224) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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