31 Results for "

endosomal membrane

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "endosomal membrane" in MCE Product Catalog:

19
DOTAP methylsulfate
DOTAP methylsulfate
0 Images
19 Publications Verification
Referencia número: HY-W127378
No. CAS: 144189-73-1
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .
loading...
    loading...
View All Sizes
3
Endosidin-2
Endosidin-2
0 Images
3 Cited Publications
Referencia número: HY-120821
No. CAS: 1839524-44-5
Pureza:  99.17%
Synonyms: ES2
Target:  

Exosomes

Áreas de investigación:  

Others

Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting) .
loading...
    loading...
View All Sizes
1
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE
0 Images
1 Cited Publications
Referencia número: HY-W583868
No. CAS: 26662-94-2
Synonyms: 1,2-POPE; 16:0-18:1 PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
loading...
    loading...
View All Sizes
GALA
GALA
0 Images
Referencia número: HY-P5423
No. CAS: 107658-43-5
Target:  

Exosomes Liposome

Áreas de investigación:  

Cancer

GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .
loading...
    loading...
View All Sizes
INF7
INF7
0 Images
Referencia número: HY-P10152
No. CAS: 185462-59-3
Target:  

Biochemical Assay Reagents

Áreas de investigación:  

Infection

INF7 is a derivative of the N-terminal domain of the HA2 protein and is sensitive to pH. INF7 disrupts the stability of endosomal membranes through a mechanism independent of membrane fusion. INF7 can be used to enhance the endosome escape of complex or liposome-encapsulated proteins. Co-encapsulation of INF7 and molecular imaging probes in liposomes can enhance intracellular signaling and probe retention .
loading...
    loading...
View All Sizes
OF-02
OF-02
0 Images
Referencia número: HY-145795
No. CAS: 1883431-67-1
Pureza:  ≥98.0%
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].
loading...
    loading...
View All Sizes
RALA peptide
RALA peptide
0 Images
Referencia número: HY-P5284
No. CAS: 1613231-49-4
Target:  

Peptides

Áreas de investigación:  

Others

RALA peptide is a cationic amphiphilic delivery agent targeting cell membranes, which forms nanoparticles through electrostatic interactions with anionic drugs. RALA peptide has pH-responsive binding properties, which can enhance the α-helical conformation in an acidic environment and destroy the endosomal membrane, promote the release of drugs into the cytoplasm, and exert efficient intracellular delivery activity. RALA peptide can be used in cancer research (enhancing the activity of bisphosphonates against prostate cancer and breast cancer cells) and bone tissue engineering (promoting osteoblast collagen deposition and extracellular matrix mineralization) .
loading...
    loading...
View All Sizes
EB1 peptide
EB1 peptide
0 Images
Referencia número: HY-P4118
No. CAS: 952754-66-4
Synonyms: Penetrating analog
Target:  

Amino Acid Derivatives Peptide-Drug Conjugates (PDCs)

Áreas de investigación:  

Others

EB1 peptide (Penetrating analog) is an endosomolytic agent and siRNA delivery agent. EB1 peptide forms an amphipathic alpha helix upon protonation in early-late endosomes, drives endosomal membrane permeabilization, and enables endocytosed siRNA escape into the cytosol. EB1 peptide facilitates biologically active siRNA cellular uptake and targeted gene silencing. EB1 peptide forms complexes with siRNA. EB1 peptide can be used for drug delivery research .
loading...
    loading...
View All Sizes
NPPM 6748-481
NPPM 6748-481
0 Images
Referencia número: HY-15784
No. CAS: 432020-20-7
Pureza:  99.60%
Target:  

Fungal

Áreas de investigación:  

Infection Inflammation/Immunology

NPPM 6748-481 is a potent and selective yeast Sec14 inhibitor with a yeast Sec14 IC50 of 211 nM. NPPM 6748-481 disrupts membrane trafficking, impairing trans-Golgi network-endosomal transport and endocytic transport. NPPM 6748-481 impairs Snc1 v-SNARE recycling, secretory invertase trafficking, and vacuolar carboxypeptidase Y processing. NPPM 6748-481 can be used for research on yeast infection .
loading...
    loading...
View All Sizes
Pip6a
Pip6a
0 Images
Referencia número: HY-P10567
Target:  

Peptides

Áreas de investigación:  

Others

Pip6a is an arginine-rich cell-penetrating peptide. Pip6a has the ability to deliver associated cargoes across the plasma and endosomal membranes and is stable to serum proteolysis. Pip6a is composed of a hydrophobic core region flanked on each side by arginine-rich domains containing β-alanine and aminohexanoyl spacers. Pip6a-conjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced antisense oligonucleotide (ASO) delivery into striated muscles of myotonic dystrophy (DM1) mice .
loading...
    loading...
View All Sizes
C16-18:1 PE
C16-18:1 PE
0 Images
Referencia número: HY-174286
No. CAS: 119904-40-4
Target:  

Liposome

Áreas de investigación:  

Others

C16-18:1 PE is a lipid. C16-18:1 PE has the activity of promoting membrane fusion and enhancing endosomal escape, which can significantly improve the delivery efficiency of mRNA. C16-18:1 PE is used in the synthesis of lipid nanoparticles (LNP) .
loading...
    loading...
View All Sizes
HA2 peptide
HA2 peptide
0 Images
Referencia número: HY-P11353
No. CAS: 117138-19-9
Target:  

Small Interfering RNA (siRNA) HIV

Áreas de investigación:  

Infection Cancer

HA2 peptide is a potent pH-responsive fusion peptide derived from hemagglutinin (HA), corresponding to the N-terminal fusion peptide domain consisting of 23 amino acid residues of HIV-1 gp41 envelope glycoprotein. HA2 peptide adopts a random coil structure under physiological pH conditions; in acidic endosomes, protonation of carboxyl groups reduces negative charge, inducing a transition to an α-helical conformation that can fuse with and destabilize the endosomal membrane. After binding to membranes, the N-terminal and middle regions of HA2 peptide mainly adopt a β-strand conformation, while the C-terminal region remains unstructured. HA2 peptide induces lipid mixing and promotes aqueous content leakage from large unilamellar vesicles whose lipid composition matches that of HIV-1 viruses and target T cells. HA2 peptide is anionic and can bind to cationic peptides to achieve siRNA condensation. HA2 peptide can be used in studies related to cancer and human immunodeficiency virus (HIV) infection .
loading...
    loading...
View All Sizes
MeDZ lipid
MeDZ lipid
0 Images
Referencia número: HY-185284
Target:  

Liposome

Áreas de investigación:  

Others

MeDZ lipid is a zwitterion-type ionizable endosomal membrane destabilizer and anti-inflammatory agent that promotes endosomal escape. When incorporated into LNP formulations, MeDZ lipid enhances mRNA expression in lymph node antigen-presenting cells and promotes cytotoxic T cell activation. MeDZ lipid is compatible with existing targeted nanoparticle formulations to improve mRNA delivery efficiency .
loading...
    loading...
View All Sizes
AM4-64
AM4-64
0 Images
Referencia número: HY-D3383
Target:  

Fluorescent Dye

Áreas de investigación:  

Neurological Disease

AM4-64 is a fixable cationic styryl fluorescent dye for nerve terminals, which can be used for vesicle cycle evaluation, endocytic pathway tracing and endocytosis detection. AM4-64 inserts into the plasma membrane, is internalized via activity- or energy-dependent endocytosis, and accumulates in vesicles, endosomal compartments, vacuolar membranes, mitochondria and endolysosomal structures. The fluorescence of AM4-64 is enhanced in the membrane-bound state. AM4-64 is applicable to relevant studies on neurons, plant and fungal cells and tissues (Ex/Em = 510/750 nm) .
loading...
    loading...
View All Sizes
Mem-RhoNox
Mem-RhoNox
0 Images
Referencia número: HY-D3122
Target:  

Fluorescent Dye

Áreas de investigación:  

Others

Mem-RhoNox is a fluorescent probe used to detect labile Fe (II) on the plasma membrane surface and inside endosomes during iron uptake in live cells. Mem-RhoNox can anchor to the extracellular surface of the plasma membrane; upon contact with Fe (II), its N-oxide group undergoes a deoxygenation reaction, converting weakly fluorescent Mem-RhoNox into strongly fluorescent Mem-Rhodamine. During transferrin-mediated endocytosis, Mem-RhoNox enters endosomes together with the transferrin-transferrin receptor complex, and reacts with Fe (II) released by transferrin to enable detection of endosomal Fe (II) .
loading...
    loading...
View All Sizes
GALA-Cys
GALA-Cys
0 Images
Referencia número: HY-P5423C
Target:  

Peptides

Áreas de investigación:  

Others

GALA-Cys is a chemically modified GALA peptide (HY-P5423) that retains GALA functions while acquiring strong covalent conjugation capability. GALA-Cys undergoes pH-driven reversible secondary structure transition, rearranges into an amphipathic α-helix, self-oligomerizes, penetrates lipid membranes to form pores, and disrupts lipid bilayers, thereby enabling endosomal escape and cytosolic cargo delivery. GALA-Cys can be conjugated with lipid DPTE for integration into liposomes, self-assembles into a tilted monolayer on gold surfaces, and serves as a pH-responsive coating for particle surface functionalization. GALA-Cys is applicable to studies related to targeted cargo delivery .
loading...
    loading...
View All Sizes
C16-pHD108
C16-pHD108
0 Images
Referencia número: HY-P11301
Target:  

Biochemical Assay Reagents

Áreas de investigación:  

Neurological Disease Cancer

C16-pHD108 is a pH-responsive nanopore-forming peptide. C16-pHD108 functions as a macromolecule delivery carrier via endosomal membrane nanoporation. C16-pHD108 is promising for research of cancers and neurodegenerative diseases .
loading...
    loading...
View All Sizes
ARN-75039
ARN-75039
0 Images
Referencia número: HY-W1135843
No. CAS: 2436472-47-6
Target:  

Arenavirus

Áreas de investigación:  

Infection

ARN-75039 is an orally active arenavirus inhibitor. ARN-75039 binds to sites on the GP2 subunit of the mammarenavirus glycoprotein complex, stabilizes prefusion conformation, and blocks viral entry and endosomal membrane fusion to inhibit viral replication and spread. ARN-75039 can be used for the research of lassa fever, arenaviral hemorrhagic fever, and lethal Junín virus infection .
loading...
    loading...
View All Sizes
SMA-245
SMA-245
0 Images
Referencia número: HY-187472
Target:  

Filovirus Cytochrome P450 Potassium Channel

Áreas de investigación:  

Infection

SMA-245 is an inhibitor of Filovirus glycoproteins, acting on Ebola virus (EBOV) and Marburg virus (MARV). SMA-245 blocks the endosomal membrane fusion step of filoviruses by binding to the EBOV GP1/GP2 fusion loop. SMA-245 inhibits MARV viral entry. SMA-245 can be used in research related to filovirus infections .
loading...
    loading...
View All Sizes
Myr-transportan-Cys
Myr-transportan-Cys
0 Images
Referencia número: HY-P11759
Target:  

Drug Derivative

Áreas de investigación:  

Cancer

Myr-transportan-Cys is a derivative of the cell-penetrating peptide Transportan (HY-P1732), and its conjugated myristoyl group (Myr) enhances the interaction between the peptide and cell membranes. Myr-transportan-Cys integrates three key delivery functions: nucleic acid condensation, cell penetration, and endosomal escape. Myr-transportan-Cys can form immunostimulatory tandem peptide nanocomplexes (iTPNCs) for encapsulating and delivering immunostimulatory oligonucleotide cargos to tumors .
loading...
    loading...
View All Sizes
Assay Types