2. Metabolic Enzyme/Protease
  3. Liposome
  4. MeDZ lipid

MeDZ lipid is a zwitterion-type ionizable endosomal membrane destabilizer and anti-inflammatory agent that promotes endosomal escape. When incorporated into LNP formulations, MeDZ lipid enhances mRNA expression in lymph node antigen-presenting cells and promotes cytotoxic T cell activation. MeDZ lipid is compatible with existing targeted nanoparticle formulations to improve mRNA delivery efficiency.

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MeDZ lipid

MeDZ lipid Chemical Structure

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MeDZ lipid Related Antibodies

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Description

MeDZ lipid is a zwitterion-type ionizable endosomal membrane destabilizer and anti-inflammatory agent that promotes endosomal escape. When incorporated into LNP formulations, MeDZ lipid enhances mRNA expression in lymph node antigen-presenting cells and promotes cytotoxic T cell activation. MeDZ lipid is compatible with existing targeted nanoparticle formulations to improve mRNA delivery efficiency[1].

In Vitro

MeDZ lipid (10 min; pH 7.4-5.5) exhibits pH-responsive protonation, transitioning from a zwitterionic state with bound H2O at pH ≥6.8 to a positively charged state with bound H3O+ at pH <6.8, as detected via 1H NMR spectroscopy[1].
LNPs containing 25 mol% MeDZ lipid (1 μg/mL mRNA; 3 h incubation, 24 h expression incubation) maximize EGFP mRNA expression in DC2.4 cells, with 1.7-fold higher expression than control LNPs despite equivalent cellular uptake[1].
LNPs containing 25 mol% MeDZ lipid (pH 6.0) exhibit enhanced membrane disruption activity at acidic pH (6.0) compared to control LNPs, supporting improved endosomal escape capability[1].
LNPs containing 25 mol% MeDZ lipid (15 μg/mL; 1.5 h incubation) exhibit enhanced endosomal escape in DC2.4 cells, as shown by reduced co-localization with endosomes/lysosomes (PCC = 0.78) compared to control LNPs (PCC = 0.90)[1].
LNPs containing 25 mol% MeDZ lipid (1 μg/mL OVA mRNA; 6 h incubation, 24 h expression/presentation incubation) enhance OVA antigen expression and presentation in BMDCs, with OVA protein levels at ~100% of control LNPs and 16.0% H2Kb-SIINFEKL-positive cells post-treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MeDZ lipid Related Antibodies
In Vivo

MeDZ (25%) LNPs (5 μg Luc mRNA per mouse; s.c.; single injection) deliver mRNA to mouse lymph nodes with 1.7-fold higher endosomal escape efficiency than BNT162b2 LNPs, resulting in enhanced luciferase expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

929.40

Formula

C56H100N2O8
SMILES

O=C(OCCCCCCN(CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)CCCCOC(C1=CC=[N+](CC([O-])=O)C=C1)=O)C(CCCCCC)CCCCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MeDZ lipid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MeDZ lipidLiposomemelanomaendosomal membrane destabilizerDC2.4 cellsanti-inflammatory agentmRNAendosomesneutrophillymph node antigen-presenting cellsBMDCscytotoxic T cellInhibitorinhibitorinhibit

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