his+tag

By Targets:	Biochemical Assay Reagents (8) Endonuclease (1) Fructose-1,6-bisphosphate aldolase (1) Fungal (1) Integrin (1) Interleukin Related (1) Ser/Thr Protease (2) STAT (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99227

*Caplacizumab (His Tag)* 1 Publications Verification ALX-0681; ALX-0081	Integrin Transmembrane Glycoprotein	Cardiovascular Disease
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP) .

HY-P0294

Hexa-His 6X His Tag	Biochemical Assay Reagents	Others
Hexa-His (6X His Tag) is a commonly used affinity tag made up of six histidine residues. HEXA-HIS can bind to affinity chromatography media containing transition metal ions like nickel (Ni ²⁺) or cobalt (Co ²⁺), making it useful for protein purification .

HY-D1288A

tris-NTA	Biochemical Assay Reagents	Others
tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins .

HY-D2355

tris-NTA Biotin	Biochemical Assay Reagents	Others
Tris-NTA Biotin is a biotin-labeled version of tris-NTA. Tris-NTA Biotin, as a bridge connecting His-tagged proteins with streptavidin, can reversibly label proteins and cell surfaces. Tris-NTA Biotin can be used in experiments such as protein immobilization, kinetic determination, live cell labeling, and Western blot detection .

HY-P99759

*Nogapendekin alfa (his tag)* IL-15N72D	Interleukin Related	Inflammation/Immunology Cancer
Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL)-15 variant, is a superagonist of IL-15. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8 ⁺ T cells .

HY-P0294A

Hexa-His TFA 6X His Tag TFA	Biochemical Assay Reagents	Others
Hexa-His TFA is a peptide consisting of 6 His residues, used as a metal binding site for the recombinant protein .

HY-E70565

O-Glycoprotease	Endonuclease	Inflammation/Immunology
O-Glycoprotease is an O-glycoprotein-specific endoprotease that catalyzes the hydrolysis of peptide bonds directly adjacent to the O-polymer in native mucin-type O-glycosylated proteins. O-Glycoprotease sequence is from Akkermansia muciniphila, recombinantly expressed in E.coli, with a 6×His tag at the C-terminus. The enzyme maintains high activity between pH 5.5-7.5 and is resistant to 1M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn ²⁺.

HY-P11421

Cys-His Tag	Biochemical Assay Reagents	Others
Cys-His Tag is a dual-purpose protein tag combining a cysteine residue and a Histidine tag. Cys-His Tag can be used to improve marker specificity or introduce covalent binding sites .

HY-P991370

*SBT-100 (His Tag)*	STAT	Cancer
SBT-100 (His Tag) is a human monoclonal antibody (mAb) targeting STAT3. SBT-100 (His Tag) inhibits IL-6-mediated P-STAT3 nuclear translocation in HEp-2 and PANC-1 cells. SBT-100 (His Tag) has tumor growth inhibitory effects on MDA-MB-231 .

HY-D1288

(Rac)-tris-NTA	Biochemical Assay Reagents	Others
(Rac)-tris-NTA is a His-tagged protein ligand, which can be used to bind His-tagged proteins .

HY-W705969

tris-NTA TFA	Biochemical Assay Reagents	Others
tris-NTA TFA is a His-tagged protein ligand. tris-NTA TFA can be used alone or in combination with a fluorophore for purification and detection of His-tagged proteins .

HY-N13916

Alternaric acid	Fungal	Infection
Alternaric acid is a host-specific toxin produced by the plant fungal. In the presence of Ca ²⁺ and Mg ²⁺, Alternaric acid stimulates phosphorylation of His-tagged cytosolic kinase RiCDPK2 .

HY-E70566

Protease (Fab Cleaving)	Ser/Thr Protease	Others
Protease (Fab Cleaving) is a serine protease expressed recombinantly in E.coli with a 6×His tag at the C-terminus. Protease (Fab Cleaving) specifically digests human IgG1 at a single site above the hinge, generating intact Fab and Fc fragments within two hours without reducing conditions.

HY-E70568

Protease (O-glycan Cleaving)	Ser/Thr Protease	Others
Protease (O-glycan Cleaving) is recombinantly expressed from E.coli and contains a His tag. Protease (O-glycan Cleaving) is an O-glycan-dependent protease that digests proteins carrying mucin-type O-glycans, including sialylated substrates, glycosylated Ser and Thr residues at the N terminus. Protease (O-glycan Cleaving) digests a variety of O-glycan structures, including sialylated glycosylated core 1 and core 2 structures and Tn antigen. Protease (O-glycan Cleaving) does not digest terminally modified serine or threonine residues, nor does it digest N-glycosylation sites on glycoproteins.

HY-E71030

Aldolase A, Human	Biochemical Assay Reagents Fructose-1,6-bisphosphate aldolase	Others
Aldolase A, Human (EC 4.1.2.13) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Aldolase A, Human (EC 4.1.2.13) , fused to His-tag at N-terminus, was expressed in E.coli.

Cat. No.	Product Name	Type

HY-D2355

tris-NTA Biotin	Fluorescent Dyes
Tris-NTA Biotin is a biotin-labeled version of tris-NTA. Tris-NTA Biotin, as a bridge connecting His-tagged proteins with streptavidin, can reversibly label proteins and cell surfaces. Tris-NTA Biotin can be used in experiments such as protein immobilization, kinetic determination, live cell labeling, and Western blot detection .

Cat. No.	Product Name	Target	Research Area

HY-P0294

Hexa-His 6X His Tag	Biochemical Assay Reagents	Others
Hexa-His (6X His Tag) is a commonly used affinity tag made up of six histidine residues. HEXA-HIS can bind to affinity chromatography media containing transition metal ions like nickel (Ni ²⁺) or cobalt (Co ²⁺), making it useful for protein purification .

HY-P0294A

Hexa-His TFA 6X His Tag TFA	Biochemical Assay Reagents	Others
Hexa-His TFA is a peptide consisting of 6 His residues, used as a metal binding site for the recombinant protein .

HY-P11421

Cys-His Tag	Biochemical Assay Reagents	Others
Cys-His Tag is a dual-purpose protein tag combining a cysteine residue and a Histidine tag. Cys-His Tag can be used to improve marker specificity or introduce covalent binding sites .

Cat. No.	Product Name

HY-K0238

Ni-IDA Agarose
MCE Ni-IDA Agarose can be used for the detection and purification of His-tag proteins.

HY-K0210

*Ni-NTA His-Tag* Purification Agarose** Maximum Cited Publications 30 Publications Verification
MCE Ni-NTA His-Tag Purification Agarose, a 6% highly cross-linked agarose reagent, enables high-yield, high-purity purification of his-tagged proteins.

HY-K0241

Ni-NTA Magnetic Agarose Beads 1 Publications Verification
MCE Ni-NTA Magnetic Agarose Beads can be used for the detection and purification of His-tag proteins from various expression sources.

HY-K0240

Ni-IDA Magnetic Agarose Beads
MCE Ni-IDA Magnetic Agarose Beads can be used for the detection and purification of His-tag proteins from various expression sources.

HY-K0256

Chelating Agarose (IDA) 6FF
MCE Chelating Agarose (IDA) 6FF allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

HY-K0209

Anti-His Magnetic Beads 20+ Cited Publications
MCE Anti-His Magnetic Beads are used for immunoprecipitation (IP) of specific His-tagged proteins expressed in bacterial and mammalian cells and in vitro expression systems. The 1 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

HY-K0255

IMAC Agarose (NTA) 6FF
MCE IMAC Agarose (NTA) 6FF is prepared by covalently coupling tetradentate nitrilotriacetic acid (NTA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

IMAC Agarose (NTA) 6FF

MCE IMAC Agarose (NTA) 6FF is prepared by covalently coupling tetradentate nitrilotriacetic acid (NTA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

Cat. No.	Product Name	Target	Research Area	Image

HY-P99227

*Caplacizumab (His Tag)* 1 Publications Verification ALX-0681; ALX-0081	Integrin Transmembrane Glycoprotein	Cardiovascular Disease
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP) .

HY-P991081

*VHH antibody (His tag), Isotype Control*	Inhibitory Antibodies	Others
VHH antibody (His tag), Isotype Control is a His-tagged VHH isotype control antibody without antigen specificity. VHH antibody (His tag), Isotype Control is used solely as a negative control for VHH experiments.

HY-P99759

*Nogapendekin alfa (his tag)* IL-15N72D	Interleukin Related	Inflammation/Immunology Cancer
Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL)-15 variant, is a superagonist of IL-15. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8 ⁺ T cells .

HY-P991370

*SBT-100 (His Tag)*	STAT	Cancer
SBT-100 (His Tag) is a human monoclonal antibody (mAb) targeting STAT3. SBT-100 (His Tag) inhibits IL-6-mediated P-STAT3 nuclear translocation in HEp-2 and PANC-1 cells. SBT-100 (His Tag) has tumor growth inhibitory effects on MDA-MB-231 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N13916

Alternaric acid	Natural Products Microorganisms Source Classification	Fungal
Alternaric acid is a host-specific toxin produced by the plant fungal. In the presence of Ca ²⁺ and Mg ²⁺, Alternaric acid stimulates phosphorylation of His-tagged cytosolic kinase RiCDPK2 .

Species:	Virus (10)
Tag:	His (10)
Source:	HEK293 (5) P. pastoris (2) Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74198

	E/Envelope Protein, Dengue virus 1 (101a.a, HEK293, His) E Protein; DENV; DENV Envelope / DENV-E Protein (His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 1 (101a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

HY-P74184

	E2/Envelope Protein, Hepatitis C virus (BAA03581, HEK293, His) Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His Tag); HCV-1a E2 Protein	Virus	HEK293
	E2/Envelope Protein, Hepatitis C virus (BAA03581, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293, with C-His labeled tag.

HY-P74190

	E/Envelope Protein, Dengue virus 4 (395a.a, sf9, His) E Protein; DENV; Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E / Envelope Protein (ECD, His Tag)	Virus	Sf9 insect cells
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 4 (395a.a, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P74185

	E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His) Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His Tag); HCV-1a E2 Protein	Virus	HEK293
	E2/Envelope Protein, Hepatitis C virus (278a.a, HEK293, His) is the recombinant Virus-derived E2/Envelope protein, expressed by HEK293, with C-His labeled tag.

HY-P74194

	E/Envelope Protein, Dengue virus 2 (429a.a, sf9, His) E Protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope Protein (ECD, His Tag)	Virus	Sf9 insect cells
	E/Envelope Protein, Dengue virus 2 (429a.a, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells, with C-His labeled tag.

HY-P74191

	E/Envelope Protein, Dengue virus 4 (101a.a, HEK293, His) E Protein; DENV; Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E / Envelope Protein (aa 579-679, His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles.During entry, NS1 induces genome penetration into the host cytoplasm.E/Envelope Protein, Dengue virus 4 (101a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

HY-P74196

	E/Envelope Protein, Dengue virus 2 (102a.a, P.pastoris, His) E Protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope Protein (Domain III, His Tag)	Virus	P. pastoris
	E/Envelope Protein, Dengue virus 2 (102a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

HY-P74192

	E/Envelope Protein, Dengue virus 3 (429a.a, HEK293, His) E Protein; DENV; Dengue virus (DENV)(type 3, strain Philippines/H87/1956) E / Envelope Protein (aa 247-675, ECD, His Tag)	Virus	HEK293
	The NS1 protein plays a key role in viral budding, association with cell membranes, and facilitating the assembly of viral RNA into nucleocapsids to form mature viral particles. During entry, NS1 induces genome penetration into the host cytoplasm. E/Envelope Protein, Dengue virus 3 (429a.a, HEK293, His) is the recombinant Virus-derived E/Envelope protein, expressed by HEK293 , with C-His labeled tag.

HY-P74193

	E/Envelope Protein, Dengue virus 2 (103a.a, P.pastoris, His) E Protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope Protein (Domain III, His Tag)	Virus	P. pastoris
	E/Envelope Protein, Dengue virus 2 (103a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris, with C-His labeled tag.

HY-P74195

	E/Envelope Protein, Dengue virus 2 (399a.a, T356R, Q357E, W381R, L387R, sf9, His) E Protein; DENV; Dengue virus (DENV) (type 2, strain New Guinea C/PUO-218 hybrid) E / Envelope Protein (His Tag)	Virus	Sf9 insect cells
	E/Envelope Protein, Dengue virus 2 (399a.a, T356R, Q357E, W381R, L387R, sf9, His) is the recombinant Virus-derived E/Envelope protein, expressed by Sf9 insect cells, with C-His labeled tag.

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Host:	Mouse (4) Rabbit (2)
Reactivity:	Species independent (6)
Application:	IHC-P (3) ICC/IF (3) IP (5) WB (6) FC (3) ELISA (2)
Isotype:	IgG (3) IgG1 (2) IgG2a (1)
Conjugation:	HRP (1) Non-conjugated (5)
Clonality:	Polyclonal (1) Monoclonal (4) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80947

	*6X His-tag* (C-terminal) Antibody (YA860)** his-tag	WB, IP	Species independent
	Anti-6X His-tag (C-terminal) Antibody is a non-conjugated and Mouse origined IgG2a monoclonal antibody, targeting to 6X His-tag.

HY-P83697

	*6X His-tag* Antibody (YA3432)** 1 Publications Verification 6 His epitope tag antibody; Hexa His tag antibody; HHHHHH epitope tag antibody; HHHHHH tag antibody; His tag antibody; Polyhistidine Tag antibody;	WB, IHC-P, ICC/IF, IP, FC	Species independent
	6X His-tag Antibody is a non-conjugated and Rabbit origined IgG monoclonal antibody, targeting to 6X His-tag.

HY-P80947A

	His Tag Antibody (HRP) (YA877) 1 Publications Verification	WB	Species independent
	His Tag Antibody (HRP) (YA877) is a HRP-conjugated, mouse-derived IgG monoclonal antibody, targeting to His Tag.

HY-P84927

	His Tag Antibody (YA4624) 1 Publications Verification 6 His tag; HHHHHH tag	WB, IP, IHC-P, ICC/IF, FC, ELISA	Species independent
	His Tag Antibody (YA4624) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to His Tag.

HY-P84927A

	His Tag Antibody (YA4624)(PBS only) 6 His tag; HHHHHH tag	WB, IP, IHC-P, ICC/IF, FC, ELISA	Species independent
	His Tag Antibody (YA4624) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to His Tag.

HY-P80959

	*6X His Tag* (C-terminal) Antibody**	WB, IP	Species independent
	His Tag Antibody is a non-conjugated and Rabbit origined IgG polyclonal antibody, targeting to His-tag.

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