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impurity synthesis

" in MedChemExpress (MCE) Product Catalog:

62

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2

Biochemical Assay Reagents

2

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7

Isotope-Labeled Compounds

1

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W010712
    Fmoc-His(Trt)-OH
    1 Publications Verification

    		 Amino Acid Derivatives Others
    Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration .
    Fmoc-His(Trt)-OH
  • HY-13036A
    IBT6A

    		Btk Cancer
    IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
    IBT6A
  • HY-W035903
    Ethanolamine hydrochloride
    1 Publications Verification

    2-Aminoethanol hydrochloride

    		 Biochemical Assay Reagents Others
    Ethanolamine hydrochloride, is an organic compound used in various industrial applications. It is a white or colorless solid that is soluble in water and has a faint odor. One of the major uses of Ethanolamine hydrochloride is in the production of detergents and surfactants. Used as a raw material in the manufacture of compounds such as ethylenediaminetetraacetic acid (EDTA) and diethanolamine, which are commonly used in household and industrial cleaning products. Ethanolamine hydrochloride is also used in the synthesis of pharmaceuticals, agrochemicals and rubber processing agents. It acts as a buffer in certain chemical reactions, helping to adjust pH and maintain stability. Ethanolamine hydrochloride can be used for gas purification and metal corrosion inhibitor. Its ability to react with acid gases such as carbon dioxide and sulfur dioxide makes it useful for removing impurities from natural gas and other industrial gases. Overall, Ethanolamine hydrochloride is a multifunctional compound with many potential industrial applications. Its ability to act as a buffer, chelating agent, and corrosion inhibitor makes it an important tool in a variety of industries.
    Ethanolamine hydrochloride
  • HY-78727
    Ibrutinib deacryloylpiperidine

    IBT4A

    		 Drug Intermediate Btk Inflammation/Immunology Cancer
    Ibrutinib deacryloylpiperidine (IBT4A) is a derivative of an Ibrutinib (HY-10997) intermediate and an Ibrutinib impurity. Ibrutinib deacryloylpiperidine serves as a starting material and is used in the synthesis of a modified BTK inhibitor derivative via the Mitsunobu reaction .
    Ibrutinib deacryloylpiperidine
  • HY-43384
    Chloromethyl methyl carbonate

    Tenofovir impurity 66

    		 Drug Intermediate Others
    Chloromethyl methyl carbonate (Tenofovir Impurity 66) is a drug intermediate for synthesis of various active compounds.
    Chloromethyl methyl carbonate
  • HY-W206016
    3-Aminosalicylic acid

    3-ASA

    		 Drug Intermediate Others
    3-Aminosalicylic acid (3-ASA) is a hydroxybenzoic acid compound. 3-Aminosalicylic acid serves as a building block for organic synthesis. It also acts as a potential impurity of 5-Aminosalicylic Acid (HY-15027) .
    3-Aminosalicylic acid
  • HY-66004
    4-Acetamidophenyl acetate

    Diacetamate

    		 Drug Intermediate Bacterial Parasite Inflammation/Immunology Cancer
    4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
    4-Acetamidophenyl acetate
  • HY-131280
    Devaleryl Valsartan Impurity

    		Drug Metabolite Others
    Devaleryl Valsartan Impurity is an intermediate in the synthesis of Valsartan .
    Devaleryl Valsartan Impurity
  • HY-59121A
    Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate

    		Drug Intermediate Infection
    Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate can be used to synthesis Sofosbuvir (HY-15005) to avoid the production of sofibuvir degradation impurities .
    Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate
  • HY-Z9064
    1-epi-Regadenoson ethyl ester

    		Drug Intermediate Others
    1-epi-Regadenoson ethyl ester is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist .
    1-epi-Regadenoson ethyl ester
  • HY-79716
    2,3-Dimethyl-6-nitro-2H-indazole

    Pazopanib impurity

    		 Drug Intermediate Others
    2,3-Dimethyl-6-nitro-2H-indazole (Pazopanib Impurity) is a drug intermediate for synthesis of various active compounds.
    2,3-Dimethyl-6-nitro-2H-indazole
  • HY-W016644
    (S)-1-Benzylpyrrolidin-3-ol

    		Drug Intermediate Cardiovascular Disease Others
    (S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322) .
    (S)-1-Benzylpyrrolidin-3-ol
  • HY-W036121
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

    UR-144 impurity 3

    		 Cannabinoid Receptor Neurological Disease
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone (UR-144 Impurity 3) is a precursor in the synthesis of synthetic cannabinoids.
    (1H-Indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
  • HY-133624
    1,1,3-Tribromoacetone
    1 Publications Verification

    		 Drug Metabolite Cancer
    1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519) . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis .
    1,1,3-Tribromoacetone
  • HY-B2121
    6-Methoxy-2-naphthoic acid

    6-MNA; Naproxen impurity O

    		 Drug Metabolite COX Neurological Disease Inflammation/Immunology
    6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds .
    6-Methoxy-2-naphthoic acid
  • HY-W072385
    1,2-Dibromo-4,5-methylenedioxybenzene

    		Drug Derivative Neurological Disease
    1,2-Dibromo-4,5-methylenedioxybenzene is an impurity in the synthesis of amphetamines .
    1,2-Dibromo-4,5-methylenedioxybenzene
  • HY-W018697
    3-Bromo-4-chlorobenzoic acid

    Dapagliflozin impurity 50

    		 Drug Intermediate Others
    3-Bromo-4-chlorobenzoic acid (Dapagliflozin Impurity 50) is a drug intermediate for synthesis of various active compounds.
    3-Bromo-4-chlorobenzoic acid
  • HY-W016194
    1-(Carboxymethyl)cyclohexanecarboxylic acid

    1-Carboxycyclohexaneacetic acid; Gabapentin impurity E; Gabapentin Related Compound E

    		 5-HT Receptor Neurological Disease
    1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.
    1-(Carboxymethyl)cyclohexanecarboxylic acid
  • HY-75318
    (5-Amino-2-butylbenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone

    Dronedarone impurity A

    		 Drug Intermediate Others
    (5-Amino-2-butylbenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone (Dronedarone impurity A) is a drug intermediate for synthesis of various active compounds.
    (5-Amino-2-butylbenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone
  • HY-78066
    Abemaciclib Impurity 1

    6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

    		 Drug Intermediate Others
    Abemaciclib Impurity 1 (6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole) is a drug intermediate for synthesis of various active compounds.
    Abemaciclib Impurity 1
  • HY-W043676
    Dibenzosuberol

    		Parasite Drug Intermediate Infection
    Dibenzosuberol (Compound 2) is a key intermediate in the synthesis of compounds associated with inhibiting Trypanosoma thiol reductase (TryR). Dibenzosuberol also shows inhibition of T. brucei with an EC50 value of 51.3 μM. Dibenzosuberol is also an impurity of Amitriptyline (HY-B0527) .
    Dibenzosuberol
  • HY-13036
    (Rac)-IBT6A

    		Btk Cancer
    (Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
    (Rac)-IBT6A
  • HY-42476
    Tolvaptan Impurity

    1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

    		 Drug Intermediate Others
    Tolvaptan Impurity (1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one) is a drug intermediate for synthesis of various active compounds.
    Tolvaptan Impurity
  • HY-W036175
    4-Acetamido-5-chloro-2-methoxybenzoic acid

    Metoclopramide impurity 12

    		 Drug Intermediate Others
    4-Acetamido-5-chloro-2-methoxybenzoic acid (Metoclopramide Impurity 12) is a drug intermediate for synthesis of various active compounds.
    4-Acetamido-5-chloro-2-methoxybenzoic acid
  • HY-59121C
    Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate

    Sofosbuvir impurity 4/Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate

    		 Drug Intermediate Others
    Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate (Sofosbuvir impurity 4/Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate) is a drug intermediate for synthesis of various active compounds.
    Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-D-alaninate
  • HY-Y1066
    2-(2-Chloroethoxy)ethanol

    Diethylene glycol monochlorohydrin

    		 Drug Intermediate Others
    2-(2-Chloroethoxy)ethanol (Diethylene glycol monochlorohydrin) is an unclassified residual solvent and known impurity, with an acceptance criterion of 0.10%.2-(2-Chloroethoxy)ethanol serves as a starting material in quetiapine synthesis .
    2-(2-Chloroethoxy)ethanol
  • HY-135397
    (R)-​Linezolid

    (R)-PNU-100766

    		 Drug Metabolite Infection
    (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis .
    (R)-​Linezolid
  • HY-13036B
    IBT6A hydrochloride

    		Btk Cancer
    IBT6A hydrochloride is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
    IBT6A hydrochloride
  • HY-179396
    T-1228

    		Bacterial Infection
    T-1228 is a highly selective LpxC inhibitor. T-1228 can effectively block the synthesis of LPS (HY-D1056), causing defects in the bacterial outer membrane structure, increasing membrane permeability, and ultimately leading to bacterial cell death. T-1228 can be used for the study of Gram-negative bacterial infections .
    T-1228
  • HY-66004R
    4-Acetamidophenyl acetate (Standard)

    Diacetamate (Standard)

    		 Reference Standards Drug Intermediate Bacterial Parasite Inflammation/Immunology Cancer
    4-Acetamidophenyl acetate (Standard) is the analytical standard of 4-Acetamidophenyl acetate (HY-66004). This product is intended for research and analytical applications. 4-Acetamidophenyl acetate is an impurity of Acetaminophen (HY-66005). 4-Acetamidophenyl acetate acts as an intermediate in the synthesis of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
    4-Acetamidophenyl acetate (Standard)
  • HY-W585843
    1,1′-Ethylidenebis[L-tryptophan]

    		Interleukin Related Inflammation/Immunology
    1,1′-Ethylidenebis[L-tryptophan] is an impurity in the synthesis of L-tryptophan. 1,1′-Ethylidenebis[L-tryptophan] promotes the proliferation of eosinophilic leukemia cells, induces the release of eosinophil cationic protein from eosinophils, and stimulates T cells to produce IL-5. 1,1′-Ethylidenebis[L-tryptophan] (40 µg/kg) can induce fascia thickening, mast cell infiltration, and fibrosis in adipose and subcutaneous muscle tissues in mice. 1,1′-Ethylidenebis[L-tryptophan] can be used in immunology and inflammation research .
    1,1′-Ethylidenebis[L-tryptophan]
  • HY-Z8863
    Citalopram impurity 1

    		Biochemical Assay Reagents Others
    Citalopram impurity 1 (Compound iv) is an amide impurity generated during the synthesis of Citalopram (HY-121203) .
    Citalopram impurity 1
  • HY-76937
    Impurity of Doxercalciferol

    		VD/VDR Endocrinology
    Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol (vitamin D2), used as a agent for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis and secretion.
    Impurity of Doxercalciferol
  • HY-119326
    N-Formylmethamphetamine

    		Drug Intermediate Neurological Disease
    N-Formylmethamphetamine is an impurity in the synthesis of methamphetamine. N-Formylmethamphetamine is also a by-product of the Nagai reaction .
    N-Formylmethamphetamine
  • HY-131391
    m-Isobutyl Ibuprofen

    		Drug Intermediate Others
    m-Isobutyl Ibuprofen (Compound IMP-A) is the impurity found during synthesis of Ibuprofen (HY-78131) .
    m-Isobutyl Ibuprofen
  • HY-Z9065
    1-epi-Regadenoson hydrazone

    		Drug Intermediate Others
    1-epi-Regadenoson hydrazone is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist .
    1-epi-Regadenoson hydrazone
  • HY-17626B
    Alalevonadifloxacin hydrochloride

    WCK-2349 hydrochloride

    		 Antibiotic Infection
    Alalevonadifloxacin (hydrochloride) (WCK-2349 (hydrochloride)) is a oraaly active anti-methicillin-resistant Staphylococcus aureus (MRSA) antibiotic .
    Alalevonadifloxacin hydrochloride
  • HY-134554
    5′-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine

    		Drug Derivative Cancer
    5′-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine is an impurity in the synthesis of Capecitabine (HY-B0016) .
    5′-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine
  • HY-120955
    (+)-5-trans Cloprostenol

    		Prostaglandin Receptor Others
    Cloprostol, a synthetic derivative of prostaglandin F2α, is used as an ossified in veterinary medicine and the research of reproductive disorders in cattle, pigs and horses. (+)-5-trans Cloprostenol is a secondary impurity produced during the synthesis of (+) -cloprostenol .
    (+)-5-trans Cloprostenol
  • HY-163967
    Clindamycin 2,4-diphosphate

    		Biochemical Assay Reagents Bacterial Infection
    Clindamycin 2,4-diphosphate is a related impurity of Clindamycin phosphate (HY-B1064), a prodrug of Clindamycin (HY-B1455). Clindamycin phosphate inhibits protein synthesis by targeting the bacterial ribosomal 50S subunit .
    Clindamycin 2,4-diphosphate
  • HY-135774R
    6-Hydroxybenzbromarone (Standard)

    		Reference Standards Drug Metabolite Phosphatase Cardiovascular Disease
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid. This product is intended for research and analytical applications. 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.
    6-Hydroxybenzbromarone (Standard)
  • HY-W016194R
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard)

    1-Carboxycyclohexaneacetic acid (Standard); Gabapentin impurity E (Standard); Gabapentin Related Compound E (Standard)

    		 5-HT Receptor Reference Standards Neurological Disease
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid. This product is intended for research and analytical applications. 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard)
  • HY-W767047
    α-Hydroxymethyl atropine-d5

    		Isotope-Labeled Compounds Drug Intermediate Others
    α-Hydroxymethyl atropine-d5 is the deuterium labeled α-Hydroxymethyl atropine (HY-W587927). α-Hydroxymethyl atropine is the impurity, that could be produced in process of Atropine (HY-B1205) synthesis .
    α-Hydroxymethyl atropine-d5
  • HY-13036C
    (Rac)-IBT6A hydrochloride

    		Btk Cancer
    (Rac)-IBT6A hydrochloride is a racemate of IBT6A hydrochloride. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM .
    (Rac)-IBT6A hydrochloride
  • HY-135397R
    (R)-?Linezolid (Standard)

    (R)-PNU-100766 (Standard)

    		 Drug Metabolite Reference Standards Infection
    (R)-​Linezolid (Standard) is the analytical standard of (R)-​Linezolid. This product is intended for research and analytical applications. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis .
    (R)-?Linezolid (Standard)
  • HY-W394935
    Dixylyl disulphide

    Disulfide,bis(2,4-dimethylphenyl)

    		 Biochemical Assay Reagents Others
    Dixylyl disulphide (Disulfide, bis(2,4-dimethylphenyl)) is a 1,2-bis(2,4-dimethylphenyl) thioether that can serve as an impurity reference standard for hydrobromide vortioxetine, used for monitoring impurities in the synthesis process. Hydrobromide vortioxetine is a 5-HT3, 5-HT7, and 5-HT1D receptor antagonist and a 5-HT1A receptor agonist, exhibiting antidepressant activity .
    Dixylyl disulphide
  • HY-W206016S
    3-Aminosalicylic acid-d3

    3-ASA-d3

    		 Isotope-Labeled Compounds Others
    3-Aminosalicylic acid-d3 is deuterium labeled 3-Aminosalicylic acid. 3-Aminosalicylic acid (3-ASA) is a hydroxybenzoic acid compound. 3-Aminosalicylic acid serves as a building block for organic synthesis. It also acts as a potential impurity of 5-Aminosalicylic Acid (HY-15027) .
    3-Aminosalicylic acid-d3
  • HY-135397S
    (R)-Linezolid-d3

    		Isotope-Labeled Compounds Infection
    (R)-Linezolid-d3 ((R)-PNU-100766-d3) is the deuterium labeled (R)-Linezolid. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis .
    (R)-Linezolid-d3
  • HY-104077S2
    Remdesivir impurity 9-d4

    		Isotope-Labeled Compounds DNA/RNA Synthesis SARS-CoV Infection
    Remdesivir impurity 9-d4 is deuterium labeled Remdesivir (HY-104077). Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .
    Remdesivir impurity 9-d4
  • HY-78558
    Tofacitinib Impurity T

    3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanamide

    		 Drug Intermediate Others
    Tofacitinib Impurity T (3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanamide) is a drug intermediate for synthesis of various active compounds.
    Tofacitinib Impurity T

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