1-(Carboxymethyl)cyclohexanecarboxylic acid (Synonyms: 1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E; Gabapentin Related Compound E)

Cat. No.: HY-W016194 Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.

For research use only. We do not sell to patients.

1-(Carboxymethyl)cyclohexanecarboxylic acid Chemical Structure

CAS No. : 67950-95-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of 1-(Carboxymethyl)cyclohexanecarboxylic acid:

1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) Get quote

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View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

5-HT_2A Receptor

Molecular Weight

186.21

Formula

C₉H₁₄O₄

CAS No.

67950-95-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC1(C(O)=O)CCCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (537.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3703 mL	26.8514 mL	53.7028 mL
5 mM	1.0741 mL	5.3703 mL	10.7406 mL
10 mM	0.5370 mL	2.6851 mL	5.3703 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.0%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) HNMR (246 KB) LCMS (77 KB)

Handling Instructions (2659 KB)

References

[1]. Ragham, et al. Development and validation of a stability-indicating RP-HPL C-CAD method for gabapentin and its related impurities in presence of degradation products. J. Pharm. Biomed. Anal. 125, 122-129 (2016).

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.3703 mL	26.8514 mL	53.7028 mL	134.2570 mL
	5 mM	1.0741 mL	5.3703 mL	10.7406 mL	26.8514 mL
	10 mM	0.5370 mL	2.6851 mL	5.3703 mL	13.4257 mL
	15 mM	0.3580 mL	1.7901 mL	3.5802 mL	8.9505 mL
	20 mM	0.2685 mL	1.3426 mL	2.6851 mL	6.7129 mL
	25 mM	0.2148 mL	1.0741 mL	2.1481 mL	5.3703 mL
	30 mM	0.1790 mL	0.8950 mL	1.7901 mL	4.4752 mL
	40 mM	0.1343 mL	0.6713 mL	1.3426 mL	3.3564 mL
	50 mM	0.1074 mL	0.5370 mL	1.0741 mL	2.6851 mL
	60 mM	0.0895 mL	0.4475 mL	0.8950 mL	2.2376 mL
	80 mM	0.0671 mL	0.3356 mL	0.6713 mL	1.6782 mL
	100 mM	0.0537 mL	0.2685 mL	0.5370 mL	1.3426 mL

1-(Carboxymethyl)cyclohexanecarboxylic acid Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-(Carboxymethyl)cyclohexanecarboxylic acid67950-95-21-Carboxycyclohexaneacetic acid Gabapentin Impurity E Gabapentin Related Compound E5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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