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  3. 1,1,3-Tribromoacetone

1,1,3-Tribromoacetone 

Cat. No.: HY-133624
Handling Instructions

1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.

For research use only. We do not sell to patients.

1,1,3-Tribromoacetone Chemical Structure

1,1,3-Tribromoacetone Chemical Structure

CAS No. : 3475-39-6

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Description

1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519)[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].

In Vivo

Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

294.77

Formula

C₃H₃Br₃O

CAS No.

3475-39-6

SMILES

O=C(CBr)C(Br)Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

1,1,3-TribromoacetoneOthersImpurityMethotrexateInhibitorinhibitorinhibit

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1,1,3-Tribromoacetone
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HY-133624
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