(R)-Linezolid-d3
(R)-Linezolid-d3 ((R)-PNU-100766-d3) is the deuterium labeled (R)-Linezolid. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis.
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- CAS. Nr.: 1795786-02-5
- Formel: C16H17D3FN3O4
- Molecular Weight:340.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1795786-02-5
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Unlabeled CAS 872992-20-6
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Molecular Weight 340.36
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Formel C16H17D3FN3O4
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SMILES
O=C1N(C[C@@H](CNC(C([2H])([2H])[2H])=O)O1)C2=CC(F)=C(C=C2)N3CCOCC3
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Synonyms
(R)-PNU-100766-d3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Bednarek E, et al. NMR and molecular modeling study, as complementary techniques to capillary electrophoresis method to elucidate the separation mechanism of linezolid enantiomers. J Chromatogr A. 2008 Jun 6;1193(1-2):164-71. [Content Brief]
[3]. Clemett D, et al. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(R)-Linezolid-d3 Related Classifications
HY-135397S Related Classifications
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