1. Protein Tyrosine Kinase/RTK
  2. Btk
  3. Ibrutinib deacryloylpiperidine

Ibrutinib deacryloylpiperidine (Synonyms: IBT4A)

Cat. No.: HY-78727
Handling Instructions

Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM.

For research use only. We do not sell to patients.

Ibrutinib deacryloylpiperidine Chemical Structure

Ibrutinib deacryloylpiperidine Chemical Structure

CAS No. : 330786-24-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
100 mg USD 55 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib[1]. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM[2].

Molecular Weight

303.32

Formula

C₁₇H₁₃N₅O

CAS No.

330786-24-8

SMILES

NC1=C2C(NN=C2C3=CC=C(OC4=CC=CC=C4)C=C3)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (82.42 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2968 mL 16.4842 mL 32.9685 mL
5 mM 0.6594 mL 3.2968 mL 6.5937 mL
10 mM 0.3297 mL 1.6484 mL 3.2968 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (8.24 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

Ibrutinib deacryloylpiperidineIBT4ABtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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Product Name:
Ibrutinib deacryloylpiperidine
Cat. No.:
HY-78727
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