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Results for "

ortho

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

2

Fluorescent Dyes

1

Biochemical Assay Reagents

1

Peptides

4

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W015600
    2-Acetamidophenol

    orthocetamol

    		 Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR Cardiovascular Disease Inflammation/Immunology
    2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe 2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .
    2-Acetamidophenol
  • HY-W015302
    2-Aminobenzenesulfonic acid

    Orthanilic acid; 2-Aminobenzenesulphonic acid

    		 Drug Intermediate Others
    2-Aminobenzenesulfonic acid is an anilinesulfonic acid and also the ortho-isomer of aminobenzenesulfonic acid. 2-Aminobenzenesulfonic acid can be used in the synthesis of other active compounds. 2-Aminobenzenesulfonic acid can coordinate via its -NH2 and -SO3 groups to form polymeric copper (II) complexes .
    2-Aminobenzenesulfonic acid
  • HY-124467
    Difludiazepam

    Ro 07-4065

    		 GABA Receptor Neurological Disease
    Difludiazepam (Ro 07-4065), a benzodiazepine derivative, is a GABAA receptor ligand with an IC50 of 4.1 nM. Difludiazepam binds to an allosteric site on the GABAA receptor to potentiate the receptor's response to GABA, reducing neuron excitability. Difludiazepam contains halogenated groups at the ortho position of its phenyl ring .
    Difludiazepam
  • HY-107848
    DL-O-Tyrosine

    NSC 72345; ortho-tyrosine; o-DL-Tyrosine; o-Tyrosine

    		 Amino Acid Derivatives Others
    DL-O-Tyrosine is a tyrosine derivative .
    DL-O-Tyrosine
  • HY-125372
    2-Amino benzamidoxime

    ABAO

    		 Biochemical Assay Reagents Others
    2-Amino benzamidoxime (ABAO) acts as a bioconjugation reagent precursor and a fluorescent probe precursor. 2-Amino benzamidoxime contains an aniline group for imine activation of aldehydes, as well as a nucleophilic group (Nu:) located at the ortho position of the amine, which is responsible for intramolecular cyclization. 2-Amino benzamidoxime reacts with glyoxal at the N-terminus of phage-displayed peptide libraries. Derivatives of 2-Amino benzamidoxime can be used for protein bioconjugation. Derivatives of 2-Amino benzamidoxime serve as fluorescent probes .\n
    2-Amino benzamidoxime
  • HY-148964
    Thiotraniliprole

    HY366

    		 Insecticide Others
    Thiotraniliprole (HY366) is an ortho formamidobenzamide insecticide that can be used for the synthesis of insecticidal combinations. Thiotraniliprole has potential applications in the prevention of lepidoptera pests, coleoptera pests, ants, and termites .
    Thiotraniliprole
  • HY-W015600R
    2-Acetamidophenol (Standard)

    orthocetamol (Standard)

    		 Reference Standards Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR Cardiovascular Disease Inflammation/Immunology
    2-Acetamidophenol (Standard) is the analytical standard of 2-Acetamidophenol. This product is intended for research and analytical applications. 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe 2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .
    2-Acetamidophenol (Standard)
  • HY-146332
    Collagen-IN-1

    		P-selectin Cardiovascular Disease
    Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC50 value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research .
    Collagen-IN-1
  • HY-W661499
    Orellanine

    		Phosphatase Apoptosis Reactive Oxygen Species (ROS) Caspase Cancer
    Orellanine, a nephrotoxic alkaloid found in Cortinarius orellanus, is an orally active and selective non-competitive inhibitor of alkaline phosphatase. Orellanine chelates iron, generates reactive oxygen species (ROS), induces DNA scission, forms ortho-semiquinone radicals, downregulates antioxidant defenses, and inhibits mitochondrial function. Orellanine induces caspase 8/9-mediated apoptosis. Orellanine inhibits synthesis of proteins, RNA, DNA, and mitochondrial protein synthesis, with metabolic activation required for cell-free protein synthesis inhibition. Orellanine can be used for the research of metastatic clear cell renal cell carcinoma, acute renal failure, chronic renal insufficiency, and kidney damage .
    Orellanine
  • HY-W015600S
    2-Acetamidophenol-d3

    orthocetamol-d3

    		 Isotope-Labeled Compounds Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR Cardiovascular Disease Inflammation/Immunology
    2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .
    2-Acetamidophenol-d3
  • HY-144577S
    Ortho-hydroxy atorvastatin-d5 calcium

    		Isotope-Labeled Compounds Others
    Ortho-hydroxy atorvastatin-d5 calcium is the deuterium labeled Ortho-hydroxy atorvastatin (HY-144577) . Ortho-hydroxy atorvastatin is the metabolic of Atorvastatin (HY-B0589) .
    Ortho-hydroxy atorvastatin-d5 calcium
  • HY-15626
    ortho-iodoHoechst 33258
    3 Publications Verification

    		 Fluorescent Dye Others
    ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    ortho-iodoHoechst 33258
  • HY-D0234
    o-Cresolphthalein

    ortho-Cresolphthalein

    		 Endogenous Metabolite Others
    o-Cresolphthalein (ortho-Cresolphthalein) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
    o-Cresolphthalein
  • HY-158857
    ortho-CBNQ

    o-Cannabinolquinone; ortho-Cannabinolquinone; o-CBNQ

    		 Cannabinoid Receptor Neurological Disease
    ortho-CBNQ (o-Cannabinolquinone) is an oxidative byproduct of Cannabidiol.
    ortho-CBNQ
  • HY-150341
    Ortho-methyl 4-anilino-1-boc-piperidine

    		Opioid Receptor Neurological Disease
    Ortho-methyl 4-anilino-1-boc-piperidine is a precursor in the synthesis of a compound.
    Ortho-methyl 4-anilino-1-boc-piperidine
  • HY-136346S
    Ortho-hydroxy atorvastatin lactone-d5

    		Drug Metabolite Cardiovascular Disease
    Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
    Ortho-hydroxy atorvastatin lactone-d5
  • HY-D2286
    HBT-Fl-BnB

    		Fluorescent Dye Others
    HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO - in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO - .
    HBT-Fl-BnB
  • HY-CE01896
    Ortho-coumaroyl-CoA

    ortho-coumaroyl-coenzyme A

    		 Biochemical Assay Reagents Metabolic Disease
    Ortho-coumaroyl-CoA (Ortho-coumaroyl-coenzyme A) is a coenzyme A derivative .
    Ortho-coumaroyl-CoA
  • HY-175108
    Despropionyl 2'-fluoro ortho-fluorofentanyl

    2'-Fluoro ortho fluoro ANPP; Despropionyl 2'-fluoro o-FF; Despropionyl 2'-fluoro ortho-FF

    		 Drug Derivative Neurological Disease
    Despropionyl 2'-fluoro ortho-Fluorofentanyl (2'-Fluoro ortho fluoro ANPP; Despropionyl 2'-fluoro o-FF; Despropionyl 2'-fluoro ortho-FF) is opioid compound and can be used for the research of neurological disease.
    Despropionyl 2'-fluoro ortho-fluorofentanyl
  • HY-W753779
    8-Hydroxygenistein

    8-OHG

    		 Reactive Oxygen Species (ROS) NO Synthase Others
    8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O₂⁻). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein (HY-14596). The content of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r = 0.959), and it remains highly stable even after being heated in boiling water for 60 minutes. During the brewing and storage of soy sauce, 8-Hydroxygenistein effectively prevents oxidative damage, making it promising for use in food antioxidant research.
    8-Hydroxygenistein
  • HY-131496S
    ortho-Topolin riboside-d4

    		Isotope-Labeled Compounds Others
    ortho-Topolin riboside-d4 is deuterium labeled ortho-Topolin riboside .
    ortho-Topolin riboside-d4
  • HY-131496
    ortho-Topolin riboside

    		STAT Cancer
    ortho-Topolin riboside is a naturally occurring cytokinin secreted from Populus x robusta leaves after sunrise. ortho-Topolin riboside has shown unique cytotoxic activity against NCI60 cell lines compared with the activity of other cytokinins.ortho-Topolin riboside induced differentiation through inhibition of STAT3 signaling in acute myeloid leukemia HL-60 cells.
    ortho-Topolin riboside
  • HY-W101542
    Metoprolol impurity 1

    ortho-Metoprolol

    		 Drug Intermediate Others
    Metoprolol impurity 1 (ortho-Metoprolol) is an impurity of Metoprolol (HY-17503).
    Metoprolol impurity 1
  • HY-W101542R
    Metoprolol impurity 1 (Standard)

    ortho-Metoprolol (Standard)

    		 Reference Standards
    1-(Isopropylamino)-3-(2-(2-methoxyethyl)phenoxy)propan-2-ol (Standard) is the analytical standard of 1-(Isopropylamino)-3-(2-(2-methoxyethyl)phenoxy)propan-2-ol. This product is intended for research and analytical applications.
    Metoprolol impurity 1 (Standard)
  • HY-179654
    ST13

    		HDAC Apoptosis Cancer
    ST13, an ortho-hydroxyanilide, is a selective, slow- and tight-binding HDAC1 and HDAC2 inhibitor with IC50s of 23 nM and 49 nM, respectively. ST13 shows a weak inhibition of HDAC3 (IC50 = 4.30 μM) and HDAC6 (IC50 > 10 μM). The induced fit mechanism of ST13 proceeds through a two-step process: first, the enzyme and inhibitor rapidly form a collision complex (EI), which then slowly transforms into the stable complex E*I. ST13 induces apoptosis in cancer cells. ST13 can be used for the study of melanoma and triple-negative breast .
    ST13

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