2-Acetamidophenol-d3
Based on 1 Customer Validation
2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 122258-87-1
- Formula: C8H6D3NO2
- Molecular Weight:154.18
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
GPX4 |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 122258-87-1
-
Unlabeled Cas 129609-18-3
-
Appearance Solid
-
Molecular Weight 154.18
-
Formula C8H6D3NO2
-
Color Off-white to light yellow
-
SMILES
OC1=C(NC(C([2H])([2H])[2H])=O)C=CC=C1
-
Synonyms
Orthocetamol-d3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (648.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Zang X, et al. 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Mar Drugs. 2024 Nov 13;22(11):513. [Content Brief]
[2]. Andrusenko I, et al. The Crystal Structure of Orthocetamol Solved by 3D Electron Diffraction. Angew Chem Int Ed Engl. 2019 Aug 5;58(32):10919-10922. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4859 mL | 32.4296 mL | 64.8593 mL | 162.1481 mL |
| 5 mM | 1.2972 mL | 6.4859 mL | 12.9719 mL | 32.4296 mL | |
| 10 mM | 0.6486 mL | 3.2430 mL | 6.4859 mL | 16.2148 mL | |
| 15 mM | 0.4324 mL | 2.1620 mL | 4.3240 mL | 10.8099 mL | |
| 20 mM | 0.3243 mL | 1.6215 mL | 3.2430 mL | 8.1074 mL | |
| 25 mM | 0.2594 mL | 1.2972 mL | 2.5944 mL | 6.4859 mL | |
| 30 mM | 0.2162 mL | 1.0810 mL | 2.1620 mL | 5.4049 mL | |
| 40 mM | 0.1621 mL | 0.8107 mL | 1.6215 mL | 4.0537 mL | |
| 50 mM | 0.1297 mL | 0.6486 mL | 1.2972 mL | 3.2430 mL | |
| 60 mM | 0.1081 mL | 0.5405 mL | 1.0810 mL | 2.7025 mL | |
| 80 mM | 0.0811 mL | 0.4054 mL | 0.8107 mL | 2.0269 mL | |
| 100 mM | 0.0649 mL | 0.3243 mL | 0.6486 mL | 1.6215 mL |
Powered by Bioz