2. Others Immunology/Inflammation Metabolic Enzyme/Protease Apoptosis NF-κB
  3. LDLR Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Isotope-Labeled Compounds
  4. 2-Acetamidophenol-d3

2-Acetamidophenol-d3  (Synonyms: Orthocetamol-d3)

Cat. No.: HY-W015600S Purity: 99.48%
COA
SDS
Handling Instructions Technical Support

2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation.

For research use only. We do not sell to patients.

2-Acetamidophenol-d<sub>3</sub>

2-Acetamidophenol-d3 Chemical Structure

CAS No. : 122258-87-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solution
10 mM * 1 mL in DMSO Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
Solid
1 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
5 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
10 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
50 mg   Get quote  
100 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2-Acetamidophenol-d3:

2-Acetamidophenol-d3 Related Antibodies

Top Publications Citing Use of Products

View All Glutathione Peroxidase Isoform Specific Products:

View All Isoforms
GPX1 GPX4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation[1][2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

GPX4

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Acetamidophenol-d3 Related Antibodies
Molecular Weight

154.18

Formula

C8H6D3NO2
CAS No.
Unlabeled CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=C(NC(C([2H])([2H])[2H])=O)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (648.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4859 mL 32.4296 mL 64.8593 mL
5 mM 1.2972 mL 6.4859 mL 12.9719 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.4859 mL 32.4296 mL 64.8593 mL 162.1481 mL
5 mM 1.2972 mL 6.4859 mL 12.9719 mL 32.4296 mL
10 mM 0.6486 mL 3.2430 mL 6.4859 mL 16.2148 mL
15 mM 0.4324 mL 2.1620 mL 4.3240 mL 10.8099 mL
20 mM 0.3243 mL 1.6215 mL 3.2430 mL 8.1074 mL
25 mM 0.2594 mL 1.2972 mL 2.5944 mL 6.4859 mL
30 mM 0.2162 mL 1.0810 mL 2.1620 mL 5.4049 mL
40 mM 0.1621 mL 0.8107 mL 1.6215 mL 4.0537 mL
50 mM 0.1297 mL 0.6486 mL 1.2972 mL 3.2430 mL
60 mM 0.1081 mL 0.5405 mL 1.0810 mL 2.7025 mL
80 mM 0.0811 mL 0.4054 mL 0.8107 mL 2.0269 mL
100 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6215 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

2-Acetamidophenol-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Acetamidophenol-d3122258-87-1Orthocetamol-d3LDLRFerroptosisReactive Oxygen Species (ROS)Glutathione PeroxidaseIsotope-Labeled CompoundsLow-density lipoprotein receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
2-Acetamidophenol-d3
Cat. No.:
HY-W015600S
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.