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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

pepsin protease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HIV Protease (6) Amino Acid Derivatives (2) Autophagy (5) Beta-secretase (2) Drug Derivative (1) Endogenous Metabolite (2) Fungal (1) HIV (1) NO Synthase (2) Reference Standards (3)
By Research Areas:	Endocrinology (3) Infection (9) Inflammation/Immunology (5) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Virus Protease HCV Protease HIV Protease Protease Activated Receptor (PAR) ClpP TMPRSS6 Calpain Serpin Enteropeptidase Ser/Thr Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0018

Pepstatin Maximum Cited Publications 59 Publications Verification Pepstatin A	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

HY-P1635

Pepsin 3 Publications Verification EC 3.4.23.1	Endogenous Metabolite	Endocrinology
Pepsin is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin contributes to proteolysis of food proteins in the vertebrate stomach .

HY-E70198

Pepsin (MS Grade) 3 Publications Verification EC 3.4.23.1 (MS Grade)	Endogenous Metabolite	Others
Pepsin (MS Grade) is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin (MS Grade) contributes to proteolysis of food proteins in the vertebrate stomach .

HY-10472

LY2811376 10+ Cited Publications	Beta-secretase	Neurological Disease
LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC₅₀ of 239 nM-249 nM, that acts to decrease Aβ secretion with EC₅₀ of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

HY-101877

Statine (3S,4S)-Statine; (S,S)-Statine	Amino Acid Derivatives	Endocrinology
Statine is an unusual amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against *pepsin* and other acid proteases.

HY-P0018A

Pepstatin Trifluoroacetate Maximum Cited Publications 59 Publications Verification Pepstatin A Trifluoroacetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

HY-P0018B

Pepstatin Ammonium Maximum Cited Publications 59 Publications Verification Pepstatin A Ammonium	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

HY-P10383

SPSB2-iNOS inhibitory cyclic peptide-1	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P0018C

Pepstatin acetate Pepstatin A acetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease .

HY-P0018R

Pepstatin (Standard) Pepstatin A (Standard)	Reference Standards HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Standard) is the analytical standard of Pepstatin. This product is intended for research and analytical applications. Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease[1][2].

HY-101877R

Statine (Standard) (3S,4S)-Statine (Standard); (S,S)-Statine (Standard)	Amino Acid Derivatives Reference Standards	Endocrinology
Statine (Standard) is the analytical standard of Statine. This product is intended for research and analytical applications. Statine is an unusual amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.

HY-N5185

Cyclothiazomycin	Fungal	Infection
Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity .

HY-P10383A

SPSB2-iNOS inhibitory cyclic peptide-1 TFA	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-1(HY-P10383). SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-N16703

3,5,7-Trihydroxy-8-methoxyflavone	Drug Derivative	Others
3,5,7-Trihydroxy-8-methoxyflavone is a natural flavonoid.

HY-P1998

Pepsinostreptin	Others	Others
Pepsinostreptin is an enzyme inhibitor with the activity of inhibiting pepsin. Pepsinostreptin can form a 1:1 complex with pepsin and significantly inhibit its activity. The activity of pepsinostreptin makes it have important application potential in the study of protease inhibition and related biological processes .

HY-10472R

LY2811376 (Standard)	Reference Standards Beta-secretase	Neurological Disease
LY2811376 (Standard) is the analytical standard of LY2811376 (HY-10472). This product is intended for research and analytical applications. LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC₅₀ of 239 nM-249 nM, that acts to decrease Aβ secretion with EC₅₀ of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

HY-182316

P-1946	HIV Protease HIV	Infection
P-1946 is a HIV protease inhibitor with a human HIV-1 protease K_i of 2.600 nM. P-1946 has potent and selective in vitro antiviral activity and retains full antiviral activity against HIV isolates resistant to commercially available protease inhibitors. P-1946 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection .

Cat. No.	Product Name	Target	Research Area

HY-P0018

Pepstatin Maximum Cited Publications 59 Publications Verification Pepstatin A	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

HY-P0018A

Pepstatin Trifluoroacetate Maximum Cited Publications 59 Publications Verification Pepstatin A Trifluoroacetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

HY-P0018B

Pepstatin Ammonium Maximum Cited Publications 59 Publications Verification Pepstatin A Ammonium	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

HY-P10383

SPSB2-iNOS inhibitory cyclic peptide-1	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

HY-P0018C

Pepstatin acetate Pepstatin A acetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease .

HY-P0018R

Pepstatin (Standard) Pepstatin A (Standard)	Reference Standards HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Standard) is the analytical standard of Pepstatin. This product is intended for research and analytical applications. Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease[1][2].

HY-P10383A

SPSB2-iNOS inhibitory cyclic peptide-1 TFA	NO Synthase	Infection
SPSB2-iNOS inhibitory cyclic peptide-1 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-1(HY-P10383). SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with K_D of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment .

Pepstatin Maximum Cited Publications 59 Publications Verification Pepstatin A	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification Cancer	HIV Protease Autophagy
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

Pepstatin Trifluoroacetate Maximum Cited Publications 59 Publications Verification Pepstatin A Trifluoroacetate	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	HIV Protease Autophagy
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

Pepstatin Ammonium Maximum Cited Publications 59 Publications Verification Pepstatin A Ammonium	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	HIV Protease Autophagy
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

Pepstatin (Standard) Pepstatin A (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards HIV Protease Autophagy
Pepstatin (Standard) is the analytical standard of Pepstatin. This product is intended for research and analytical applications. Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease[1][2].

Cyclothiazomycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity .

3,5,7-Trihydroxy-8-methoxyflavone	Structural Classification Flavonols Flavonoids Muntingia calabura L. Plants Muntingiaceae Source Classification	Drug Derivative
3,5,7-Trihydroxy-8-methoxyflavone is a natural flavonoid.

Pepsinostreptin	Natural Products Microorganisms Source Classification	Others
Pepsinostreptin is an enzyme inhibitor with the activity of inhibiting pepsin. Pepsinostreptin can form a 1:1 complex with pepsin and significantly inhibit its activity. The activity of pepsinostreptin makes it have important application potential in the study of protease inhibition and related biological processes .

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pepsin protease

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
Products