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Cat. No.: HY-182316

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P-1946

P-1946 is a HIV protease inhibitor with a human HIV-1 protease K_i of 2.600 nM. P-1946 has potent and selective in vitro antiviral activity and retains full antiviral activity against HIV isolates resistant to commercially available protease inhibitors. P-1946 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection.

For research use only. We do not sell to patients.

CAS No.: 449806-40-0
Formula: C₂₉H₄₁N₅O₆S
Molecular Weight:587.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

P-1946 Chemical Structure

CAS No.: 449806-40-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

HIV-1

2.6 nM (Ki)

All HIV Isoforms :

In Vitro

P-1946 potently and selectively inhibits wild-type HIV-1 protease with a K_i of 2.600 ± 0.076 nM, while displaying weak activity against human cathepsin D and porcine pepsin (IC₅₀ ≥30 μM)^[1].
P-1946 (6 days) potently inhibits replication of wild-type HIV-1 strains NL4-3 and RF in MT-4 cells with EC₅₀ values of 152 nM and 136 nM, respectively, has a CC₅₀ of 40 μM, and a selectivity index of 263 for MT-4 cells^[1].
P-1946 (6 days) retains full antiviral activity against 8 of 11 PI-resistant HIV-1 strains in MT-4 cells or via PhenosenseTM assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 449806-40-0
Molecular Weight 587.73
Formula C₂₉H₄₁N₅O₆S
SMILES

O=S(N(CC(C)C)[C@H](CO)CCCCNC([C@@H](NC(OC)=O)CC1=CNC2=CC=CC=C12)=O)(C3=CC=C(C=C3)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sévigny G, et al. Antiviral activity and cross-resistance profile of P-1946, a novel human immunodeficiency virus type 1 protease inhibitor. Antiviral Res. 2006;70(2):17-20. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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P-1946

All HIV Isoforms