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Cat. No.: HY-N5185

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Cyclothiazomycin

Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity.

For research use only. We do not sell to patients.

CAS No.: 133352-26-8
Formula: C₅₉H₆₄N₁₈O₁₄S₇
Molecular Weight:1473.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

Cyclothiazomycin Chemical Structure

CAS No.: 133352-26-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity^[1].

Chemical Information

CAS No. 133352-26-8
Molecular Weight 1473.71
Formula C₅₉H₆₄N₁₈O₁₄S₇
SMILES

C=C(NC([C@@H]1CSC(C2=CSC(C3=CC=C(C(N[C@H](C4=N[C@H](C(N/C(C(N[C@@](C)(SC5)C6=O)=O)=C\C)=O)CS4)CC(N)=O)=O)C([C@H](NC([C@@H]7CCCN7C(/C(NC(CNC([C@@H](N6)[C@@H](C)O)=O)=O)=C/C)=O)=O)C)=N3)=N2)=N1)=O)C8=NC(C9=NC(C%10=N[C@H](C(N[C@@H]5C(O)=O)=O)CS%10)=CS9)=CS8
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces NR0516
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. M Aoki, et al. Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization. J Antibiot (Tokyo). 1991 Jun;44(6):582-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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