Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization

  • J Antibiot (Tokyo). 1991 Jun;44(6):582-8. doi: 10.7164/antibiotics.44.582.
M Aoki  1 ,  T Ohtsuka ,  M Yamada ,  Y Ohba ,  H Yoshizaki ,  H Yasuno ,  T Sano ,  J Watanabe ,  K Yokose ,  H Seto
Affiliations
  • 1. Nippon Roche Research Center, Kanagawa, Japan.
PMID: 2071486 DOI: 10.7164/antibiotics.44.582
Abstract

Cyclothiazomycin is a novel Renin Inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography and preparative HPLC. Cyclothiazomycin, which was determined to be a unique polythiazole-containing bicyclic peptide, exhibited inhibitory activity against human plasma Renin with IC50 being 1.7 microM.

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