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sterol compound

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (2) Apoptosis (4) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (1) Cytochrome P450 (3) Drug Derivative (3) Drug Intermediate (4) Endogenous Metabolite (1) Fungal (4) FXR (1) p38 MAPK (2) Potassium Channel (1) PROTACs (1) Reactive Oxygen Species (ROS) (2) Reference Standards (3)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (5) Metabolic Disease (1)

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Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-N0410

Daucosterol 5 Publications Verification Eleutheroside A; β-Sitosterol β-D-glucoside	Apoptosis Reactive Oxygen Species (ROS) Autophagy	Inflammation/Immunology Cancer
Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .

HY-N7255

Cycloartenol 2 Publications Verification	p38 MAPK Apoptosis	Cancer
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

HY-N1200

Stigmasterol glucoside	5 alpha Reductase	Inflammation/Immunology Cancer
Stigmasterol glucoside is a sterol compound and a 5α-reductase inhibitor with an IC₅₀ value of 27.2 µM. Stigmasterol glucoside has certain anti-inflammatory, antioxidant, and anti-tumor activities .

HY-119847

Abafungin BAY-W-6341	Fungal	Infection
Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses .

HY-W740611

Trihydroxycoprostane	Drug Intermediate	Inflammation/Immunology
Trihydroxycoprostane (THCP) is a polyhydroxysterane compound with a 5β configuration. ITrihydroxycoprostane acts as a key intermediate in the biosynthesis of bile acids from cholesterol and also serves as an important sterol metabolite generated by host-gut microbiota interactions. Trihydroxycoprostane can be used for mechanistic studies of diseases such as non-alcoholic fatty liver disease, inflammatory bowel disease, and bile acid metabolism disorders .

HY-B1734

16-Dehydropregnenolone acetate 16-DPA	FXR 5 alpha Reductase Cytochrome P450 Drug Intermediate	Cardiovascular Disease Cancer
16-Dehydropregnenolone acetate (16-DPA), a sterols compound, is an orally active 17α-hydroxylase and 5α-reductase inhibitor. 16-Dehydropregnenolone is also a potent bile acid receptor (BAR)/farnesoid X receptor (FXR) antagonist. 16-Dehydropregnenolone hypolipidemic and anticancer effects. 16-Dehydropregnenolone acetate (16-DPA) is the drug intermediate that can be used for synthesis of Dexamethasone (HY-14648) and related other steroidal pharmacophores .

HY-N0410R

Daucosterol (Standard) Eleutheroside A (Standard); β-Sitosterol β-D-glucoside (Standard)	Reference Standards Apoptosis Reactive Oxygen Species (ROS) Autophagy	Inflammation/Immunology Cancer
Daucosterol (Standard) is the analytical standard of Daucosterol. This product is intended for research and analytical applications. Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .

HY-160804

Desmethyl nevanimibe	Drug Intermediate	Cancer
Desmethyl nevanimibe (Compound 5) is the demethyl precursor of the sterol O-acyltransferase 1 (SOAT1) inhibitor Nevanimibe (PD-132301) .

HY-158728

28-Deoxybetulin methyleneamine	Drug Derivative	Others
28-Deoxybetulin methyleneamine (compound 36) is a derivative of Betulin. Betulin (HY-N0083) is a sterol regulatory element-binding protein (SREBP) inhibitor .

HY-D2336

PROTAC Aster-A degrader-1	PROTACs	Cancer
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

HY-163631

Antibacterial agent 218	Fungal Endogenous Metabolite	Infection
Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC₅₀ of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC₅₀ of 0.25 μg/mL .

HY-N7255R

Cycloartenol (Standard)	Reference Standards p38 MAPK Apoptosis	Cancer
Cycloartenol (Standard) is the analytical standard of Cycloartenol. This product is intended for research and analytical applications. Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

HY-W422288

(Rac)-Ketoconazole (Rac)-Ketoconazol; (Rac)-R 41400	Fungal Cytochrome P450	Infection
(Rac)-Ketoconazole ((Rac)-R 41400) is an antifungal imidazole compound with oral activity. (Rac)-Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac)-Ketoconazole is indicated for studies of fungal infections .

HY-176210

CYP51-IN-24	Fungal Cytochrome P450	Infection
CYP51-IN-24 (Compound 22) is a Sterol 14α-Demethylase (CYP51) inhibitor. CYP51-IN-24 exhibits potent inhibitory activity against wild-type and drug-resistant fungi. CYP51-IN-24 inhibits ergosterol biosynthesis by binding to the fungal CYP51 enzyme. CYP51-IN-24 can be used in research and drug development against drug-resistant fungal infections .

HY-118843

Lombazole	Potassium Channel	Infection
Lombazole is an antimicrobial compound with activity that inhibits cell membrane synthesis. Lombazole had little effect on K+ permeability in S. aureus. Lombazole inhibited only de novo synthesis of cell enclosure in S. aureus, and this effect occurred before growth was affected. The main effect of lombazole was through inhibition of lipid synthesis. Lombazole may have an effect on key steps in lipid biosynthesis, as inferred from the lack of changes in lipid patterns after treatment. Lombazole also inhibited the sterol C-14 demethylation step in Candida albicans .

HY-116079

Diplopterol	Drug Derivative	Others
Diplopterol is a hopane compound that can be purified from Rhodopseudomonas palustris TIE-1. Diplopterol acts as a sterol substitute .

HY-N19578

5α,6α-Epoxystigmasterol	Drug Intermediate	Others
5α,6α-Epoxystigmasterol is a sterol epoxide. 5α,6α-Epoxystigmasterol serves as a precursor of brassinosteroidal compounds .

HY-N19063

Cassia alata extract	Bacterial	Infection Inflammation/Immunology
Cassia alata extract contains anthraquinones (including hypericic acid), flavonoids, phenolic compounds, fatty acids, natural sterols, terpenoids, and saponins, among other bioactive compounds. Cassia alata extract possesses antifungal, antibacterial, and anti-inflammatory properties and can be used in research on skin diseases such as tinea, eczema, and fungal infections.

HY-N19066

Cissus quadrangularis extract	Others	Metabolic Disease
Cissus quadrangularis extract contains a variety of bioactive compounds, such as flavonoids, phenolic acids, carotenoids, triterpenoids, vitamins, 3-ketosteroids, minerals, and sterols. Cissus quadrangularis extract can promote fracture healing, reduce bone loss, and increase bone density.

HY-N17427

(R)-(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol	Others	Others
(R)-(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol (compound 3) is a sterol that can be found in of Grifola frondosa .

HY-N17478

(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol	Drug Derivative	Others
(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (Compound 7) is a polyoxygenated sterol isolated from the sponge Homaxinella sp.

HY-167809

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine	Biochemical Assay Reagents
1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is a sterol-modified phospholipid with the activity of maintaining the stability of membrane bilayer structure and enhancing the liposome-mediated compound delivery process. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is widely used in biomedical applications to improve the delivery efficiency of compounds. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine can also improve the release and distribution of compounds in cells.

HY-34544R

2-Hexylthiophene (Standard)	Reference Standards Others	Others
Daucosterol (Standard) is the analytical standard of Daucosterol. This product is intended for research and analytical applications. Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .

Cat. No.	Nombre del producto

HY-L091

Lipid Metabolism Compound Library	978 compounds
Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation. MCE offers a unique collection of 978 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Lipid Metabolism Compound Library

978 compounds

Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation.

MCE offers a unique collection of 978 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

PROTAC Aster-A degrader-1	Fluorescent Dyes
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

Cat. No.	Nombre del producto	Type

HY-167809

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine	Biochemical Assay Reagents
1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is a sterol-modified phospholipid with the activity of maintaining the stability of membrane bilayer structure and enhancing the liposome-mediated compound delivery process. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is widely used in biomedical applications to improve the delivery efficiency of compounds. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine can also improve the release and distribution of compounds in cells.

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine

Biochemical Assay Reagents

1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is a sterol-modified phospholipid with the activity of maintaining the stability of membrane bilayer structure and enhancing the liposome-mediated compound delivery process. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine is widely used in biomedical applications to improve the delivery efficiency of compounds. 1-Palmitoyl-2-cholesterylcarbonoyl-sn-glycero-3-phosphocholine can also improve the release and distribution of compounds in cells.

Daucosterol 5 Publications Verification Eleutheroside A; β-Sitosterol β-D-glucoside	Classification of Application Fields Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Disease Research Fields Araliaceae Steroids Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) Autophagy
Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .

Cycloartenol 2 Publications Verification	Microorganisms other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	p38 MAPK Apoptosis
Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

Stigmasterol glucoside	other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	5 alpha Reductase
Stigmasterol glucoside is a sterol compound and a 5α-reductase inhibitor with an IC₅₀ value of 27.2 µM. Stigmasterol glucoside has certain anti-inflammatory, antioxidant, and anti-tumor activities .

Trihydroxycoprostane	Structural Classification Endogenous metabolite Steroids Source Classification	Drug Intermediate
Trihydroxycoprostane (THCP) is a polyhydroxysterane compound with a 5β configuration. ITrihydroxycoprostane acts as a key intermediate in the biosynthesis of bile acids from cholesterol and also serves as an important sterol metabolite generated by host-gut microbiota interactions. Trihydroxycoprostane can be used for mechanistic studies of diseases such as non-alcoholic fatty liver disease, inflammatory bowel disease, and bile acid metabolism disorders .

Daucosterol (Standard) Eleutheroside A (Standard); β-Sitosterol β-D-glucoside (Standard)	Structural Classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Steroids Source Classification	Reference Standards Apoptosis Reactive Oxygen Species (ROS) Autophagy
Daucosterol (Standard) is the analytical standard of Daucosterol. This product is intended for research and analytical applications. Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .

Cycloartenol (Standard)	Structural Classification Microorganisms other families Plants Steroids Source Classification	Reference Standards p38 MAPK Apoptosis
Cycloartenol (Standard) is the analytical standard of Cycloartenol. This product is intended for research and analytical applications. Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development .

Diplopterol	Structural Classification Microorganisms Terpenoids Pentacyclic Triterpenoids Source Classification	Drug Derivative
Diplopterol is a hopane compound that can be purified from Rhodopseudomonas palustris TIE-1. Diplopterol acts as a sterol substitute .

5α,6α-Epoxystigmasterol	Structural Classification Tetracyclic Triterpenoids Terpenoids Nigella sativa L. Ranunculaceae Plants Source Classification	Drug Intermediate
5α,6α-Epoxystigmasterol is a sterol epoxide. 5α,6α-Epoxystigmasterol serves as a precursor of brassinosteroidal compounds .

Cassia alata extract	Structural Classification Extract	Bacterial
Cassia alata extract contains anthraquinones (including hypericic acid), flavonoids, phenolic compounds, fatty acids, natural sterols, terpenoids, and saponins, among other bioactive compounds. Cassia alata extract possesses antifungal, antibacterial, and anti-inflammatory properties and can be used in research on skin diseases such as tinea, eczema, and fungal infections.

Cissus quadrangularis extract	Structural Classification Extract	Others
Cissus quadrangularis extract contains a variety of bioactive compounds, such as flavonoids, phenolic acids, carotenoids, triterpenoids, vitamins, 3-ketosteroids, minerals, and sterols. Cissus quadrangularis extract can promote fracture healing, reduce bone loss, and increase bone density.

(R)-(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol	Structural Classification Productos naturales Microorganisms Source Classification	Others
(R)-(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol (compound 3) is a sterol that can be found in of Grifola frondosa .

(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol	Structural Classification Animals Steroids Source Classification	Drug Derivative
(3β,5α,8α,22E,24ξ)-5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (Compound 7) is a polyoxygenated sterol isolated from the sponge Homaxinella sp.

2-Hexylthiophene (Standard)	Structural Classification Productos naturales Endogenous metabolite Source Classification	Reference Standards Others
Daucosterol (Standard) is the analytical standard of Daucosterol. This product is intended for research and analytical applications. Daucosterol is an orally active natural sterol compound, which has anti-inflammatory, anticancer and immunomodulatory activities. Daucosterol inhibits cancer cell proliferation by inducing autophagy through ROS-dependent manner. Daucosterol also inhibits colon cancer growth by inducing apoptosis, inhibiting cell migration and invasion and targeting caspase signalling pathway .

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sterol compound

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Bibliotecas de Screening

Fluorescent Dyes

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