16-Dehydropregnenolone acetate
16-Dehydropregnenolone acetate (16-DPA), a sterols compound, is an orally active 17α-hydroxylase and 5α-reductase inhibitor. 16-Dehydropregnenolone is also a potent bile acid receptor (BAR)/farnesoid X receptor (FXR) antagonist. 16-Dehydropregnenolone hypolipidemic and anticancer effects. 16-Dehydropregnenolone acetate (16-DPA) is the drug intermediate that can be used for synthesis of Dexamethasone (HY-14648) and related other steroidal pharmacophores.
For research use only. We do not sell to patients.
- CAS No.: 979-02-2
- Formula: C23H32O3
- Molecular Weight:356.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 979-02-2
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Molecular Weight 356.50
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Formula C23H32O3
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SMILES
CC(C1=CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(C)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
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Synonyms
16-DPA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kumar M, et al., Aza-annulation on the 16-dehydropregnenolone, via tandem intermolecular aldol process and intramolecular Michael addition. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2232-7. [Content Brief]
[2]. Ramakrishna R, Kumar D, Bhateria M, Gaikwad AN, Bhatta RS. 16-Dehydropregnenolone lowers serum cholesterol by up-regulation of CYP7A1 in hyperlipidemic male hamsters. J Steroid Biochem Mol Biol. 2017 Apr;168:110-117. [Content Brief]
[3]. Deng Z, Wang X, Wang F, Qin Z, Cui Y, Sun Y, Sun L. Pharmacokinetics and tissue distribution study of 16-dehydropregnenolone liposome in female mice after intravenous administration. Drug Deliv. 2016 Oct;23(8):2787-2795. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
16-Dehydropregnenolone acetate Related Classifications
HY-B1734 Related Classifications
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