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trypsin+inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Influenza Virus (1) PAI-1 (1) Ser/Thr Protease (11)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Inflammation/Immunology (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0017

Aprotinin 30+ Cited Publications	Influenza Virus Ser/Thr Protease	Cardiovascular Disease Cancer
Aprotinin is a *bovine pancreatic trypsin inhibitor* (BPTI)** inhibitor which inhibits *trypsin* and chymotrypsin with K_is of 0.06 pM and 9 nM, respectively.

HY-126388

Trypsin Inhibitor, soybean	Ser/Thr Protease	Others
Trypsin Inhibitor, soybean is a potent and reversible inhibitor of *trypsin* .

HY-P10033

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide *trypsin* inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms .

HY-N2028

Demethylwedelolactone	Ser/Thr Protease	Cancer
Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent *trypsin* inhibitor with an IC₅₀ of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell .

HY-W018723

4-Aminobenzamidine dihydrochloride 1 Publications Verification p-Aminobenzamidine dihydrochloride	Ser/Thr Protease PAI-1	Cardiovascular Disease Cancer
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong *trypsin* inhibitor. 4-Aminobenzamidine dihydrochloride acts as an orally active urokinase type plasminogen activator (uPA) inhibitor (K_i=82 μM). 4-Aminobenzamidine dihydrochloride can be used for cardiovascular diseases and anti-tumor study .

HY-W014134

p-APMSF hydrochloride p-Amidinophenylmethylsulfonylfluoride hydrochloride	Ser/Thr Protease	Inflammation/Immunology
p-APMSF (p-Amidinophenylmethylsulfonylfluoride) hydrochloride is a serine protease and trypsin inhibitor with the characteristic of rapid onset of action. p-APMSF hydrochloride reduces the enzymatic hydrolysis of recombinant human G-CSF in rat pulmonary mucosa. Combined intratracheal treatment with p-APMSF hydrochloride and Laureth-9 significantly enhances its absorption efficiency in rat lungs. Following intranasal administration, p-APMSF hydrochloride does not increase the concentration of recombinant human G-CSF in rat plasma, nor does it alter the effect of G-CSF on inducing an increase in total white blood cell count .

HY-165529

Camostat Maximum Cited Publications 43 Publications Verification	Ser/Thr Protease	Inflammation/Immunology
Camostat is an orally active *trypsin* inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs) .

HY-P34013

*Urinary Trypsin Inhibitor* Fragment**	Ser/Thr Protease	Cancer
Urinary Trypsin Inhibitor Fragment is a fragment derived from urinary trypsin inhibitor by proteolysis. Urinary Trypsin Inhibitor Fragment can inhibit tumor cell invasion by limited proteolysis .

HY-147167

Bz-D-Arg-pNA hydrochloride	Ser/Thr Protease	Others
Bz-D-Arg-pNA hydrochloride is a competitive *trypsin* inhibitor .

HY-19472A

RWJ-58643 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
RWJ-58643 hydrochloride is a β-trypsin inhibitor that inhibits allergic inflammation. RWJ-58643 hydrochloride (100 mg) significantly reduces nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 hydrochloride causes late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 hydrochloride modulates allergic reactions by inhibiting the release of β-trypsin from mast cells.

HY-19472

RWJ-58643	Ser/Thr Protease	Inflammation/Immunology
RWJ-58643 is a *β-trypsin* inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells .

Trypsin Inhibitor, soybean	Biochemical Assay Reagents
Trypsin Inhibitor, soybean is a potent and reversible inhibitor of *trypsin* .

Cat. No.	Product Name	Target	Research Area

HY-P0017

Aprotinin 30+ Cited Publications	Influenza Virus Ser/Thr Protease	Cardiovascular Disease Cancer
Aprotinin is a *bovine pancreatic trypsin inhibitor* (BPTI)** inhibitor which inhibits *trypsin* and chymotrypsin with K_is of 0.06 pM and 9 nM, respectively.

HY-P10033

SFTI-1	Ser/Thr Protease	Others
SFTI-1 is a cyclic peptide *trypsin* inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms .

HY-P34013

*Urinary Trypsin Inhibitor* Fragment**	Ser/Thr Protease	Cancer
Urinary Trypsin Inhibitor Fragment is a fragment derived from urinary trypsin inhibitor by proteolysis. Urinary Trypsin Inhibitor Fragment can inhibit tumor cell invasion by limited proteolysis .

Aprotinin 30+ Cited Publications	Cardiovascular Disease Natural Products Animals Disease Research Fields Source Classification	Influenza Virus Ser/Thr Protease
Aprotinin is a *bovine pancreatic trypsin inhibitor* (BPTI)** inhibitor which inhibits *trypsin* and chymotrypsin with K_is of 0.06 pM and 9 nM, respectively.

Demethylwedelolactone	Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Other Flavonoids Disease Research Fields Source Classification Cancer	Ser/Thr Protease
Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent *trypsin* inhibitor with an IC₅₀ of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell .

Species:	Human (3) Mouse (1)
Tag:	His (4) Fc (1)
Source:	HEK293 (3) P. pastoris (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702787

	Trypsin inhibitor DE-3 Protein, Erythrina caffra (P. pastoris, His) Trypsin inhibitor DE-3	Others	P. pastoris
	Trypsin inhibitor DE-3 Protein, Erythrina caffra (P. pastoris, His) is the recombinant Trypsin inhibitor DE-3, expressed by P. pastoris , with N-6*His labeled tag. ,

HY-P71053

	SPINK1 Protein, Human (HEK293, His) Pancreatic Secretory Trypsin Inhibitor; Serine Protease Inhibitor Kazal-Type 1; Tumor-Associated Trypsin Inhibitor; TATI; SPINK1; PSTI	Human	HEK293
	The SPINK1 protein is a serine protease inhibitor that significantly inhibits trypsin, especially in the pancreas, preventing premature activation of the zymogen. This critical role maintains the integrity of pancreatic cellular processes. SPINK1 Protein, Human (HEK293, His) is the recombinant human-derived SPINK1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P702493

	SPINK1 Protein, Mouse (P.pastoris, His) Pancreatic Secretory Trypsin Inhibitor; Serine Protease Inhibitor Kazal-Type 1; Tumor-Associated Trypsin Inhibitor; TATI; SPINK1; PSTI	Mouse	P. pastoris
	SPINK1 is a serine protease inhibitor that significantly inhibits trypsin, especially in the pancreas, preventing premature activation of the zymogen. In the male reproductive tract, SPINK1 binds to sperm heads and regulates sperm volume by inhibiting calcium absorption and nitrogen oxide (NO) production. SPINK1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived SPINK1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P76653

	SPINK2 Protein, Human (HEK293, Fc) Serine protease inhibitor Kazal-type 2; Acrosin-trypsin inhibitor; HUSI-II	Human	HEK293
	SPINK2, a robust acrosin inhibitor, is vital for normal spermiogenesis, preventing premature activation of proacrosin and other proteases to avoid spermiogenesis defects. It likely regulates germ cell apoptosis mediated by serine proteases and displays inhibitory activity against trypsin, indicating involvement in diverse serine protease-dependent processes. SPINK2 Protein, Human (HEK293, Fc) is the recombinant human-derived SPINK2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70407

	ITIH3 Protein, Human (HEK293, His) rHuInter-alpha-trypsin inhibitor heavy chain H3/ITIH3/, His; Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3; Serum-derived hyaluronan-associated protein; SHAP	Human	HEK293
	The ITIH3 protein has a dual role: as a carrier of hyaluronic acid in serum and as a binding protein that facilitates interactions with various matrix proteins. These interactions regulate the localization, synthesis, and degradation of hyaluronic acid, which is critical for multiple cellular activities. ITIH3 Protein, Human (HEK293, His) is the recombinant human-derived ITIH3 protein, expressed by HEK293 , with C-6*His labeled tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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