Demethylwedelolactone
Based on 1 Customer Validation
Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent trypsin inhibitor with an IC50 of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 6468-55-9
- Formula: C15H8O7
- Molecular Weight:300.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 3.0 μM (trypsin)[1]
Chemical Information
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CAS No. 6468-55-9
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Appearance Solid
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Molecular Weight 300.22
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Formula C15H8O7
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Color Light yellow to green yellow
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SMILES
O=C1C2=C(OC3=CC(O)=C(O)C=C32)C4=C(O)C=C(O)C=C4O1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (333.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Syed SD, et al. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. Phytother Res. 2003 Apr;17(4):420-1. [Content Brief]
[2]. Lee YJ, et al. Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. Eur J Med Chem. 2012 Oct;56:361-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3309 mL | 16.6545 mL | 33.3089 mL | 83.2723 mL |
| 5 mM | 0.6662 mL | 3.3309 mL | 6.6618 mL | 16.6545 mL | |
| 10 mM | 0.3331 mL | 1.6654 mL | 3.3309 mL | 8.3272 mL | |
| 15 mM | 0.2221 mL | 1.1103 mL | 2.2206 mL | 5.5515 mL | |
| 20 mM | 0.1665 mL | 0.8327 mL | 1.6654 mL | 4.1636 mL | |
| 25 mM | 0.1332 mL | 0.6662 mL | 1.3324 mL | 3.3309 mL | |
| 30 mM | 0.1110 mL | 0.5551 mL | 1.1103 mL | 2.7757 mL | |
| 40 mM | 0.0833 mL | 0.4164 mL | 0.8327 mL | 2.0818 mL | |
| 50 mM | 0.0666 mL | 0.3331 mL | 0.6662 mL | 1.6654 mL | |
| 60 mM | 0.0555 mL | 0.2776 mL | 0.5551 mL | 1.3879 mL | |
| 80 mM | 0.0416 mL | 0.2082 mL | 0.4164 mL | 1.0409 mL | |
| 100 mM | 0.0333 mL | 0.1665 mL | 0.3331 mL | 0.8327 mL |
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