Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice

  • Eur J Med Chem. 2012 Oct;56:361-7. doi: 10.1016/j.ejmech.2012.07.041.
Yean-Jang Lee  1 ,  Wea-Lung Lin ,  Nai-Fang Chen ,  Shien-Kai Chuang ,  Tsui-Hwa Tseng
Affiliations
  • 1. Department of Chemistry, National Changhua University of Education, No. 1, Jin-De Road, Changhua 500, Taiwan.
PMID: 22926226 DOI: 10.1016/j.ejmech.2012.07.041
Abstract

The Anticancer properties of demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-invasive effects of synthetic WEL and DWEL on human MDA-MB-231 breast Cancer cells. We found that WEL and DWEL inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells. In addition, WEL and DWEL reduced the activity and expression of Matrix Metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells. Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice. Altogether, these data suggest that DWEL derivatives exert anti-invasive growth effect on breast Cancer cells.

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