SFTI-1
Based on 1 Customer Validation
SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms.
For research use only. We do not sell to patients.
- Purity: 99.15%
- CAS No.: 245080-24-4
- Formula: C67H104N18O18S2
- Molecular Weight:1513.78
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SFTI-1 (0-400 nM; 2 h) shows a Ki of 0.5 nM for bovine β-trypsin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 245080-24-4
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Appearance Solid
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Molecular Weight 1513.78
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Formula C67H104N18O18S2
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Color White to off-white
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Sequence
Cyclic(Arg-Cys-Thr-Lys-Ser-Ile-Pro-Pro-Ile-Cys-Phe-Pro-Asp-Gly) (Disulfide bridge: Cys2-Cys10)
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Sequence Shortening
Cyclic(RCTKSIPPICFPDG) (Disulfide bridge: Cys2-Cys10)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (66.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. M L Korsinczky, et al. Solution structures by 1H NMR of the novel cyclic trypsin inhibitor SFTI-1 from sunflower seeds and an acyclic permutant. J Mol Biol. 2001 Aug 17;311(3):579-91. [Content Brief]
[2]. Korsinczky ML, et al. Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1. Biochemistry. 2005 Feb 1;44(4):1145-53. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6606 mL | 3.3030 mL | 6.6060 mL | 16.5149 mL |
| 5 mM | 0.1321 mL | 0.6606 mL | 1.3212 mL | 3.3030 mL | |
| 10 mM | 0.0661 mL | 0.3303 mL | 0.6606 mL | 1.6515 mL | |
| 15 mM | 0.0440 mL | 0.2202 mL | 0.4404 mL | 1.1010 mL | |
| 20 mM | 0.0330 mL | 0.1651 mL | 0.3303 mL | 0.8257 mL | |
| 25 mM | 0.0264 mL | 0.1321 mL | 0.2642 mL | 0.6606 mL | |
| 30 mM | 0.0220 mL | 0.1101 mL | 0.2202 mL | 0.5505 mL | |
| 40 mM | 0.0165 mL | 0.0826 mL | 0.1651 mL | 0.4129 mL | |
| 50 mM | 0.0132 mL | 0.0661 mL | 0.1321 mL | 0.3303 mL | |
| 60 mM | 0.0110 mL | 0.0550 mL | 0.1101 mL | 0.2752 mL |
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