2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SGS518 oxalate

SGS518 oxalate is a selective 5-HT6R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses[1]

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SGS518 oxalate

SGS518 oxalate 화학구조

CAS No. : 445441-27-0

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Other Forms of SGS518 oxalate:

SGS518 oxalate Related Antibodies

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제품 설명

SGS518 oxalate is a selective 5-HT6R antagonist. SGS518 oxalate can be used for the research of cognitive impairments such as amnesia, anxiety and depression, and it is effective in protecting mouse retina at high doses[1]

IC50 & Target[1]

5-HT6 Receptor

 

In Vivo

SGS518 oxalate (30 mg/kg; i.p. for 30 min) protects Abca4–/–Rdh8 sup>–/– mouse retinas from light-induced damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Abca4–/–Rdh8 sup>–/–mice are exposed at white light[1]
Dosage: 30 mg/kg
Administration: I.p. injection for 30 minutes
Result: A marked preservation of the photoreceptor layer.
Reduced formation of autofluorescent spots in mice.
Protected retinal morphology.
분자량

510.51

화학식

C23H24F2N2O7S
CAS No.
SMILES

O=S(C1=C(F)C=CC=C1F)(OC2=CC3=C(N(C)C=C3C4CCN(C)CC4)C=C2)=O.O=C(O)C(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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SGS518 oxalate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGS518445441-27-0SGS 518SGS-5185-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT6RcognitiveimpairmentsamnesiaanxietydepressionretinaInhibitorinhibitorinhibit

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상품명:
SGS518 oxalate
Cat. No.:
HY-19668A
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