Sodium aescinate

Name: Sodium aescinate
Brand: MedChemExpress
SKU: HY-N1404
Rating: 5.0 (2 reviews)

Art. -Nr.: HY-N1404 Reinheit: 99.26%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.

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Sodium aescinate Chemische Struktur

CAS. Nr. : 20977-05-3

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE Sodium aescinate

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle NF-κB Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities^[1]. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway^[2].

In Vitro

Sodium aescinate can block signals transiting to downstream molecules AKT, ERK, inhibit the proliferation of breast cancer cell MCF-7 cell apoptosis and induced cell apoptosis by suppressing the activation of SRC^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities^[1].
? Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-β pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Klinische Studie

Molekulargewicht

1123.21

Formel

C₅₄H₈₃NaO₂₃

CAS. Nr.

20977-05-3

Appearance

Solid

Color

White to off-white

SMILES

CC(C(OC[C@@]12[C@H]3C[C@]4(C)C([C@]1([H])CC(C)(C)[C@H](O3)[C@@H]2O)=CC[C@@]5([H])[C@@]4(C)CC[C@]6([H])[C@]5(C)CC[C@H](O[C@@H]7O[C@H](C(O[Na])=O)[C@@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O[C@@H]9OC[C@@H](O)[C@H](O)[C@H]9O)[C@]6(CO)C)=O)C(OC(C)=O)C

Structure Classification

Initial Source

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (89.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (89.03 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8903 mL	4.4515 mL	8.9031 mL
5 mM	0.1781 mL	0.8903 mL	1.7806 mL
10 mM	0.0890 mL	0.4452 mL	0.8903 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 25 mg/mL (22.26 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.26%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Zhang Z, et al. The Efficacy of Sodium Aescinate on Cutaneous Wound Healing in Diabetic Rats. Inflammation. 2015 Oct;38(5):1942-8. [Content Brief]

[2]. Hou H, et al. CARMA3/NF-κB signaling contributes to tumorigenesis of hepatocellular carcinoma and is inhibited by sodium aescinate. World J Gastroenterol. 2019 Sep 28;25(36):5483-5493. [Content Brief]

[3]. Qi SM, et al. Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3267-72. [Content Brief]

[4]. Chen L, et al. Effect of sodium aescinate treatment on PCOS rat model with insulin resistance. Bratisl Lek Listy. 2017;118(4):223-227. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	0.8903 mL	4.4515 mL	8.9031 mL	22.2576 mL
	5 mM	0.1781 mL	0.8903 mL	1.7806 mL	4.4515 mL
	10 mM	0.0890 mL	0.4452 mL	0.8903 mL	2.2258 mL
	15 mM	0.0594 mL	0.2968 mL	0.5935 mL	1.4838 mL
	20 mM	0.0445 mL	0.2226 mL	0.4452 mL	1.1129 mL
	25 mM	0.0356 mL	0.1781 mL	0.3561 mL	0.8903 mL
	30 mM	0.0297 mL	0.1484 mL	0.2968 mL	0.7419 mL
	40 mM	0.0223 mL	0.1113 mL	0.2226 mL	0.5564 mL
	50 mM	0.0178 mL	0.0890 mL	0.1781 mL	0.4452 mL
	60 mM	0.0148 mL	0.0742 mL	0.1484 mL	0.3710 mL
	80 mM	0.0111 mL	0.0556 mL	0.1113 mL	0.2782 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.