2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. STAT3-IN-20

STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis.

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STAT3-IN-20

STAT3-IN-20 화학구조

CAS No. : 2768427-54-7

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
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500 mg   견적 받기  

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STAT3-IN-20 Related Antibodies

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STAT3 STAT5 STAT6 STAT1

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  • References

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제품 설명

STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis[1].

IC50 & Target

0.65 μM (STAT3)[1]
Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
2.97 μM
Compound: 40
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
[PMID: 37594012]
HCT-116 IC50
2.19 μM
Compound: 40
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
[PMID: 37594012]
HepG2 IC50
1.45 μM
Compound: 40
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
[PMID: 37594012]
MDA-MB-231 IC50
3.26 μM
Compound: 40
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
[PMID: 37594012]
PANC-1 IC50
2.43 μM
Compound: 40
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
[PMID: 37594012]
PBMC IC50
16.3 μM
Compound: 40
Antiproliferative activity against human PBMC cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human PBMC cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
[PMID: 37594012]
분자량

593.64

화학식

C30H27F4N7S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (168.45 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6845 mL 8.4226 mL 16.8452 mL
5 mM 0.3369 mL 1.6845 mL 3.3690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6845 mL 8.4226 mL 16.8452 mL 42.1131 mL
5 mM 0.3369 mL 1.6845 mL 3.3690 mL 8.4226 mL
10 mM 0.1685 mL 0.8423 mL 1.6845 mL 4.2113 mL
15 mM 0.1123 mL 0.5615 mL 1.1230 mL 2.8075 mL
20 mM 0.0842 mL 0.4211 mL 0.8423 mL 2.1057 mL
25 mM 0.0674 mL 0.3369 mL 0.6738 mL 1.6845 mL
30 mM 0.0562 mL 0.2808 mL 0.5615 mL 1.4038 mL
40 mM 0.0421 mL 0.2106 mL 0.4211 mL 1.0528 mL
50 mM 0.0337 mL 0.1685 mL 0.3369 mL 0.8423 mL
60 mM 0.0281 mL 0.1404 mL 0.2808 mL 0.7019 mL
80 mM 0.0211 mL 0.1053 mL 0.2106 mL 0.5264 mL
100 mM 0.0168 mL 0.0842 mL 0.1685 mL 0.4211 mL
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STAT3-IN-20 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-202768427-54-7STATSTAT3 phosphorylationDU145MDA-MB-231cancerantiproliferativeInhibitorinhibitorinhibit

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상품명:
STAT3-IN-20
Cat. No.:
HY-155982
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