2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Succinyl-Coenzyme A sodium

Succinyl-Coenzyme A (sodium)  (Synonyms: Succinyl-CoA (sodium))

製品番号: HY-137808 純度: 94%
COA 取扱説明書 Technical Support

Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis).

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CAS 番号 : 108347-97-3

容量 価格（税別） 在庫状況 数量
1 mg $95 在庫あり
5 mg $285 在庫あり
10 mg $485 在庫あり
25 mg $1070 在庫あり
50 mg $1712 在庫あり
100 mg $2740 在庫あり
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Based on 3 publication(s) in Google Scholar

Other Forms of Succinyl-Coenzyme A sodium:

Succinyl-Coenzyme A (sodium) 関連抗体

Top Publications Citing Use of Products

    Succinyl-Coenzyme A sodium purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Dec 13;43(12):115060.  [Abstract]

    FLAG-TBK1 was overexpressed in HEK293T cells and immunoprecipitated using an anti-FLAG antibody. The immunoprecipitates were then treated with 2 mM Succinyl-Coenzyme A sodium (succinyl-CoA) for 15 min, followed by detection of TBK1 succinylation. The results showed that succinyl-coenzyme A sodium, a well-known precursor for protein succinylation, markedly induced succinylation of FLAG-tagged TBK1 in vitro.

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    製品説明

    Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis)[1][2][3].

    体外実験

    Succinyl CoA sodium acts as a substrate for rat liver δ-aminolevulinic acid synthase-1 with a Michaelis constant (Km) of 6-120 μmol/L[2].
    Succinyl CoA sodium does not bind to recombinant NLRX1 in an in vitro pull-down assay[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Succinyl-Coenzyme A (sodium) 関連抗体
    分子式

    C25H40N7NaO19P3S
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]([C@@H]1O[P](O)(O)=O)[C@](O[C@@H]1CO[P](O[P](OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC(O)=O)=O)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.[x].[Na]
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (Need ultrasonic and warming)

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    純度とドキュメンテーション

    純度: ≥99.0%

    COA (245 KB)

    取扱説明書 (2659 KB)
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    Succinyl-Coenzyme A sodium Related Classifications

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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    Keywords:

    Succinyl-Coenzyme A108347-97-3Succinyl-CoAEndogenous Metabolitecitric acid cyclesuccinic acidδ-ALAporphyrinshemenutritional vitamin B12 deficiencyporphyriasInhibitorinhibitorinhibit

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    製品名:
    Succinyl-Coenzyme A sodium
    製品番号:
    HY-137808
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