2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. USP5-IN-1

USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.

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USP5-IN-1

USP5-IN-1 構造式

CAS 番号 : 2851040-81-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 162 在庫あり
Solution
10 mM * 1 mL in DMSO USD 162 在庫あり
Solid
5 mg $148 在庫あり
10 mg $222 在庫あり
25 mg $400 在庫あり
50 mg $600 在庫あり
100 mg $900 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 3 publication(s) in Google Scholar

USP5-IN-1 関連抗体

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Deubiquitinase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
USP1 USP2 USP4 USP7 USP8 USP10 USP21 USP30 UCHL1 USP11 USP15 USP28 USP25

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製品説明

USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.

IC50 & Target

USP5

 

体外実験

USP5-IN-1 (2.8 μM) has a dissociation constant of 2.8 μM for USP5 ZnF-UBD and shows ≥30-fold selectivity over 9 homologous ZnF-UBD proteins[1].
USP5-IN-1 (0.8-26 μM) inhibits USP5 cleavage of Lys48-linked diubiquitin substrates in vitro in a dose-dependent manner with IC50 of 0.8 μM (DU48-03 substrate) and 26 μM (DU48-02 substrate)[1].
USP5-IN-1 (7-46 μM) displaces N-terminally fluorescently labeled ubiquitin from USP5 ZnF-UBD and full-length USP5 in a dose-dependent manner with IC50 of 7 μM and 46 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

USP5-IN-1 関連抗体
分子量

437.90

分子式

C19H20ClN3O5S
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

O=S(C1=CC=C(C(NCC(O)=O)=O)N=C1)(N2CCC(C3=CC=C(Cl)C=C3)CC2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (285.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2836 mL 11.4181 mL 22.8363 mL
5 mM 0.4567 mL 2.2836 mL 4.5673 mL
10 mM 0.2284 mL 1.1418 mL 2.2836 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2836 mL 11.4181 mL 22.8363 mL 57.0907 mL
5 mM 0.4567 mL 2.2836 mL 4.5673 mL 11.4181 mL
10 mM 0.2284 mL 1.1418 mL 2.2836 mL 5.7091 mL
15 mM 0.1522 mL 0.7612 mL 1.5224 mL 3.8060 mL
20 mM 0.1142 mL 0.5709 mL 1.1418 mL 2.8545 mL
25 mM 0.0913 mL 0.4567 mL 0.9135 mL 2.2836 mL
30 mM 0.0761 mL 0.3806 mL 0.7612 mL 1.9030 mL
40 mM 0.0571 mL 0.2855 mL 0.5709 mL 1.4273 mL
50 mM 0.0457 mL 0.2284 mL 0.4567 mL 1.1418 mL
60 mM 0.0381 mL 0.1903 mL 0.3806 mL 0.9515 mL
80 mM 0.0285 mL 0.1427 mL 0.2855 mL 0.7136 mL
100 mM 0.0228 mL 0.1142 mL 0.2284 mL 0.5709 mL
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USP5-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

USP5-IN-12851040-81-6DeubiquitinaseDUBsUSP5deubiquitinating enzymescancerZnF-UBDselectiveInhibitorinhibitorinhibit

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製品名:
USP5-IN-1
製品番号:
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