2851040-81-6
Chemical Structure
USP5-IN-1
- CAS No.: 2851040-81-6
- Formula:C19H20ClN3O5S
- Molecular Weight:437.90
IUPAC Name: (5-((4-(4-chlorophenyl)piperidin-1-yl)sulfonyl)picolinoyl)glycine
InChIKey: HIWYRXWPCQHOSO-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C(NCC(O)=O)=O)N=C1)(N2CCC(C3=CC=C(Cl)C=C3)CC2)=O
Biological Activity: USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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USP5-IN-1 | 99.73% | USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers. | ||||||||||||||||||||
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