2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. USP5-IN-1

USP5-IN-1 (compound 64), a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. USP5-IN-1 is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate.

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USP5-IN-1 Chemical Structure

USP5-IN-1 Chemical Structure

CAS No. : 2851040-81-6

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Based on 1 publication(s) in Google Scholar

USP5-IN-1 Related Antibodies

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Description

USP5-IN-1 (compound 64), a potent deubiquitinase USP5 inhibitor, binds to the USP5 ZnF-UBD with a KD of 2.8 μM. USP5-IN-1 is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate[1].

Molecular Weight

437.90

Formula

C19H20ClN3O5S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=S(C1=CC=C(C(NCC(O)=O)=O)N=C1)(N2CCC(C3=CC=C(Cl)C=C3)CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (285.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2836 mL 11.4181 mL 22.8363 mL
5 mM 0.4567 mL 2.2836 mL 4.5673 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2836 mL 11.4181 mL 22.8363 mL 57.0907 mL
5 mM 0.4567 mL 2.2836 mL 4.5673 mL 11.4181 mL
10 mM 0.2284 mL 1.1418 mL 2.2836 mL 5.7091 mL
15 mM 0.1522 mL 0.7612 mL 1.5224 mL 3.8060 mL
20 mM 0.1142 mL 0.5709 mL 1.1418 mL 2.8545 mL
25 mM 0.0913 mL 0.4567 mL 0.9135 mL 2.2836 mL
30 mM 0.0761 mL 0.3806 mL 0.7612 mL 1.9030 mL
40 mM 0.0571 mL 0.2855 mL 0.5709 mL 1.4273 mL
50 mM 0.0457 mL 0.2284 mL 0.4567 mL 1.1418 mL
60 mM 0.0381 mL 0.1903 mL 0.3806 mL 0.9515 mL
80 mM 0.0285 mL 0.1427 mL 0.2855 mL 0.7136 mL
100 mM 0.0228 mL 0.1142 mL 0.2284 mL 0.5709 mL
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USP5-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

USP5-IN-12851040-81-6DeubiquitinaseDUBsUSP5deubiquitinating enzymescancerZnF-UBDselectiveInhibitorinhibitorinhibit

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