WAY-213613

Name: WAY-213613
Brand: MedChemExpress
SKU: HY-107523
Rating: 5.0 (3 reviews)

Cat. No.: HY-107523 Purity: 99.97%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC₅₀ value of 85 nM. WAY-213613 can be used for the research of central nervous system

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CAS No. : 868359-05-1

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of WAY-213613:

WAY-213613 hydrochloride In-stock

3 Publications Citing Use of MCE WAY-213613

: WAY-213613 purchased from MedChemExpress. Usage Cited in: Ann Transl Med. 2020 Jun;8(11):691. [Abstract]; The SAH mice are intraperitoneally administered with HDAC2 inhibitor (2 mg/kg) and GLT-1 inhibitor (WAY-213613, 1 mg/kg) two weeks after surgery once every other day. The expression of GLT-1, HDAC2, p-GluN2B and p-GluA1 in hippocampus is detected after SAH at 8 weeks.

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View All EAAT Isoform Specific Products:

View All Isoforms

EAAT1 EAAT2 EAAT3 EAAT4 EAAT5

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

EAAT2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	0.08 μM Compound: 16 table 1	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2 Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2	[PMID: 16165356]
HEK293	IC₅₀	3.8 μM Compound: 16 table 1	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3 Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3	[PMID: 16165356]
HEK293	IC₅₀	5 μM Compound: 16 table 1	Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1 Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 1	[PMID: 16165356]
Oocyte	IC₅₀	130 nM Compound: 16 table 1	Inhibitory concentration against glutamate uptake in oocytes expressing in human Excitatory amino acid transporter 2 Inhibitory concentration against glutamate uptake in oocytes expressing in human Excitatory amino acid transporter 2	[PMID: 16165356]

In Vitro

WAY-213613 (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC₅₀ values of 5004 nM, 85 nM and 3787 nM, respectively^[1].
WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[³H] glutamate uptake with K_i values of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively^[1].
WAY-213613 (0-100 μM) produces a concentration-dependent block of glutamate-induced currents in EAAT1-, EAAT2- or EAAT3-injected oocytes, with IC₅₀ values of 48, 0.13 and 4.0 μM, respectively^[1].
WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

415.19

화학식

C₁₆H₁₃BrF₂N₂O₄

CAS No.

868359-05-1

Appearance

Solid

Color

White to off-white

SMILES

BrC(C=C(F)C(F)=C1)=C1OC2=CC=C(NC(C[C@H](N)C(O)=O)=O)C=C2

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (240.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4085 mL	12.0427 mL	24.0854 mL
5 mM	0.4817 mL	2.4085 mL	4.8171 mL
10 mM	0.2409 mL	1.2043 mL	2.4085 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.97%

Select Batch:

Data Sheet (272 KB) SDS (479 KB)

COA (245 KB) HNMR (263 KB) RP-HPLC (257 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. [Content Brief]

[2]. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4085 mL	12.0427 mL	24.0854 mL	60.2134 mL
	5 mM	0.4817 mL	2.4085 mL	4.8171 mL	12.0427 mL
	10 mM	0.2409 mL	1.2043 mL	2.4085 mL	6.0213 mL
	15 mM	0.1606 mL	0.8028 mL	1.6057 mL	4.0142 mL
	20 mM	0.1204 mL	0.6021 mL	1.2043 mL	3.0107 mL
	25 mM	0.0963 mL	0.4817 mL	0.9634 mL	2.4085 mL
	30 mM	0.0803 mL	0.4014 mL	0.8028 mL	2.0071 mL
	40 mM	0.0602 mL	0.3011 mL	0.6021 mL	1.5053 mL
	50 mM	0.0482 mL	0.2409 mL	0.4817 mL	1.2043 mL
	60 mM	0.0401 mL	0.2007 mL	0.4014 mL	1.0036 mL
	80 mM	0.0301 mL	0.1505 mL	0.3011 mL	0.7527 mL
	100 mM	0.0241 mL	0.1204 mL	0.2409 mL	0.6021 mL

WAY-213613 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WAY-213613868359-05-1WAY213613WAY 213613EAATExcitatory amino acid transporter Glutamate transporter| EAAT1EAAT2EAAT3central nervous systemglutamateInhibitorinhibitorinhibit

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WAY-213613

고객리뷰

Other Forms of WAY-213613:

WAY-213613 Related Antibodies

3 Publications Citing Use of MCE WAY-213613

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All EAAT Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

WAY-213613 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

WAY-213613 Related Classifications

Keywords:

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고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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