868359-05-1
868359-05-1
Chemical Structure
WAY-213613
- CAS No.: 868359-05-1
- Formula:C16H13BrF2N2O4
- Molecular Weight:415.19
IUPAC Name: N4-(4-(2-bromo-4,5-difluorophenoxy)phenyl)-L-asparagine
InChIKey: BNYDDAAZMBUFRG-ZDUSSCGKSA-N
SMILES: BrC(C=C(F)C(F)=C1)=C1OC2=CC=C(NC(C[C@H](N)C(O)=O)=O)C=C2
Biological Activity: WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC50 value of 85 nM. WAY-213613 can be used for the research of central nervous system[1][2]
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WAY-213613 | 99.97% | WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC50 value of 85 nM. WAY-213613 can be used for the research of central nervous system | ||||||||||||||||||||
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References
- [1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. [Content Brief]
- [2]. Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136. [Content Brief]
Keywords
