2. Stem Cell/Wnt PROTAC
  3. Wnt PROTACs β-catenin
  4. xStAx-VHLL

xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity.

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xStAx-VHLL

xStAx-VHLL 構造式

容量 価格（税別） 在庫状況 数量
5 mg $280 在庫あり
10 mg $450 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 3 publication(s) in Google Scholar

Other Forms of xStAx-VHLL:

xStAx-VHLL 関連抗体

Top Publications Citing Use of Products

Wnt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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製品説明

xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity[1].

体外実験

xStAx-VHLL (10-60 μM; 1-6 days) induces β-catenin degradation in a dose-dependent manner in colorectal cancer cells and inhibits cell proliferation[1].
xStAx-VHLL (50-90 μM; 24 h) inhibits Wnt/β-catenin signaling in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

xStAx-VHLL 関連抗体

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 10, 20, 30, 40, 50 and 60 μM
Incubation Time: 24 h
Result: Reduced the level of β-catenin in a dose-dependent manner.
体内実験

xStAx-VHLL (30 mg/kg; Intraperitoneal injection; 14 days) has antitumor activity in mouse intestinal tumor model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APC min/+ mice that harbored a point mutation in the APC gene, resulting in APC deletion and constitutive activation of Wnt signaling (APC min/+ mice develops intestinal tumors around 10 weeks-old) [1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection (i.p.); 14 days
Result: Dramatically reduced tumor number.
Reduced the active of β-catenin protein levels.
分子量

3231.89

分子式

C154H244N48O29
Appearance

Solid

Color

White to off-white

Sequence

Ac-Arg-Arg-Trp-Pro-Arg-{S5}-Ile-Leu-Asp-{S5}-His-Val-Arg-Arg-Val-Trp-Arg-{Ahx}-Ala-Leu-Ala-Pro-Tyr-Ile-Pro-NH2
Sequence Shortening

Ac-RRWPR{S5}ILD{S5}HVRRVWR-{Ahx}-ALAPYIP-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (30.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3094 mL 1.5471 mL 3.0942 mL
5 mM 0.0619 mL 0.3094 mL 0.6188 mL
10 mM 0.0309 mL 0.1547 mL 0.3094 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.95%

COA (255 KB) RP-HPLC (202 KB) MS (217 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3094 mL 1.5471 mL 3.0942 mL 7.7354 mL
5 mM 0.0619 mL 0.3094 mL 0.6188 mL 1.5471 mL
10 mM 0.0309 mL 0.1547 mL 0.3094 mL 0.7735 mL
15 mM 0.0206 mL 0.1031 mL 0.2063 mL 0.5157 mL
20 mM 0.0155 mL 0.0774 mL 0.1547 mL 0.3868 mL
25 mM 0.0124 mL 0.0619 mL 0.1238 mL 0.3094 mL
30 mM 0.0103 mL 0.0516 mL 0.1031 mL 0.2578 mL
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xStAx-VHLL Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

xStAx-VHLLWntPROTACsβ-cateninBeta catenincolorectal cancerHCT116 cellsHEK293T cellsInhibitorinhibitorinhibit

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製品名:
xStAx-VHLL
製品番号:
HY-P5819
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