2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  3. nAChR Parasite
  4. Zolunicant

Zolunicant  (Synonyms: MM-110; (±)​-18-Methoxycoronaridine)

製品番号: HY-147428 純度: 99.59%
COA 取扱説明書 Technical Support

Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC50 of 0.90 μM to combat addiction. Zolunicant can decrease the self-administration of several addictive agents including morphine, methamphetamine, nicotine, and ethanol in rat model. Zolunicant can be studied as a potential research for multiple forms of agent abuse. Zolunicant also reveals a potent leishmanicide effect against Leishmania amazonensis.

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Zolunicant

Zolunicant 構造式

CAS 番号 : 188125-42-0

容量 価格（税別） 在庫状況 数量
1 mg $820 在庫あり
5 mg $2050 在庫あり
10 mg $3300 在庫あり
25 mg $6600 在庫あり
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Zolunicant 関連抗体

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Parasite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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製品説明

Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC50 of 0.90 μM to combat addiction. Zolunicant can decrease the self-administration of several addictive agents including morphine, methamphetamine, nicotine, and ethanol in rat model. Zolunicant can be studied as a potential research for multiple forms of agent abuse[1]. Zolunicant also reveals a potent leishmanicide effect against Leishmania amazonensis[2].

IC50 & Target

Leishmania

 

体外実験

Zolunicant (18-MC; 0.01-100 μM) shows an inhibitory activity against nicotinic α3β4 receptors with an IC50 of 0.90 μM[1].
. Zolunicant (18-MCOR; 0-20 μg/ml; 24h) also shows antiamastigote activity against L. amazonensis-infected macrophage[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zolunicant 関連抗体

Cell Viability Assay[2]

Cell Line: L. amazonensis-infected macrophage
Concentration: 0, 1, 10,15 and 20 μg/ml
Incubation Time: 24 h
Result: Decreased the amastigote survival by 73, 84, and 92%, respectively in the treatment with 18-MCOR at 1, 10, or 20 μg/ml.
体内実験

Zolunicant (18-MC; Intravenous administration; 0-20 μg a day;14 days) decreases morphine self-administration by blocking α3β4 nicotinic receptors in the habenulo-interpeduncular pathway[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naïve female Long-Evans derived rats[3]
Dosage: 0,10 and 20 μg
Administration: Intravenous administration; once a day; 14 days
Result: Infused into the medial habenula and interpeduncular nucleus decreased morphine self-administration (interpeduncular nucleus: F(5,29) = 6.89, P < 0.0001; medial habenula: F(4,28) = 3.07, P < 0.03).
分子量

368.47

分子式

C22H28N2O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

COC([C@]12[C@@]3([H])[N@@](CCC4=C2NC5=CC=CC=C54)C[C@@](C[C@@H]3CCOC)([H])C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション
参考文献
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Zolunicant Related Classifications

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Keywords:

Zolunicant188125-42-0MM-110 (±)​-18-MethoxycoronaridineMM110MM 110nAChRParasiteNicotinic acetylcholine receptors18-MC18-Methoxycoronaridinenicotinic α3β4 receptors inhibitormorphinemethamphetaminenicotineethanoldrug abuseanti-parasiticInhibitorinhibitorinhibit

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製品番号:
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