2'-Deoxyadenosine-5'-triphosphate (Synonyms: dATP)

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2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (2'-Deoxyadenosine-5'-triphosphate trisodium) usually boasts enhanced water solubility and stability.

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2'-Deoxyadenosine-5'-triphosphate 화학구조

CAS No. : 1927-31-7

사이즈	재고
5 mg	견적 받기	Estimated Time of Arrival: December 31
10 mg	견적 받기	Estimated Time of Arrival: December 31
25 mg	견적 받기	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of 2'-Deoxyadenosine-5'-triphosphate:

2'-Deoxyadenosine-5'-triphosphate-¹³C₁₀,¹⁵N₅ (dilithium) In-stock
2'-Deoxyadenosine-5'-triphosphate-d₁₄ (dilithium) In-stock
2'-Deoxyadenosine-5'-triphosphate-¹⁵N₅ (dilithium) In-stock
2'-Deoxyadenosine-5'-triphosphate-¹³C₁₀ (dilithium) In-stock
2'-Deoxyadenosine-5'-triphosphate trisodium In-stock
2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade In-stock
2'-Deoxyadenosine-5'-triphosphate-¹³C₁₀,¹⁵N₅ (tetraammonia) 견적 받기
2'-Deoxyadenosine-5'-triphosphate-¹⁵N₅,d₁₄ (dilithium) 견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase^[1].

IC₅₀ & Target

DNA Polymerase

Human Endogenous Metabolite

In Vitro

2'-Deoxyadenosine-5'-triphosphate (dATP) (0.01-0.5 mM; 600 sec) induces dose-dependent mitochondrial permeability transition in isolated mouse liver mitochondria, with a half-maximal response at 0.03 mM, and this induction is sensitive to cyclosporin A but not z-VAD^[2].
dATP is required for apoptosome assembly and subsequent procaspase-9 activation in cell-free extracts, a key step in the intrinsic apoptotic pathway^[3].
dATP directly induces specific cytochrome c release from isolated mitochondria, initiating a key step in the intrinsic apoptotic pathway^[3].
2'-Deoxyadenosine-5'-triphosphate (dATP) (400 μM; 2 h) increases Escherichia coli K-12 membrane-damaged attached cells by over 2-fold and total attached cells by ~1.6-fold, and (400 μM; 2 h in planktonic cultures or 16 h in biofilms) increases eDNA release by 48% in planktonic cells and 200% in biofilm matrices^[4].
2'-Deoxyadenosine-5'-triphosphate (dATP) (400 μM; 60 min) increases Acinetobacter baumannii adherence to human bronchial epithelial NCI-H292 cells by 100-fold, from 1.6 × 10⁴ to 8.79 × 10⁵ CFU/cm², and promotes bacterial aggregate formation^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

분자량

491.18

화학식

C₁₀H₁₆N₅O₁₂P₃

CAS No.

1927-31-7

SMILES

O[C@H]([C@H](O1)CO[P](O[P](O[P](O)(O)=O)(O)=O)(O)=O)C[C@@H]1N2C3=NC=NC(N)=C3N=C2

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8. [Content Brief]

[2]. Yang JC, Cortopassi GA. dATP causes specific release of cytochrome C from mitochondria. Biochem Biophys Res Commun. 1998 Sep 18;250(2):454-7. [Content Brief]

[3]. Katona K, et al. Deoxy-adenosine-monophosphate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cells. Cancer Lett. 2006 Apr 28;235(2):281-90. [Content Brief]

[4]. Xi C, Wu J. dATP/ATP, a multifunctional nucleotide, stimulates bacterial cell lysis, extracellular DNA release and biofilm development. PLoS One. 2010 Oct 14;5(10):e13355. [Content Brief]

2'-Deoxyadenosine-5'-triphosphate Related Classifications

Others

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxyadenosine-5'-triphosphate1927-31-7dATPEndogenous MetaboliteDNA/RNA SynthesisInhibitorinhibitorinhibit

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